168473-87-8

Basic information

• Product Name: ETHYL 4-BROMO-3-NITROBENZOATE
• Synonyms: 4-Bromo-3-nitro-benzoic acid ethyl ester
• CAS NO: 168473-87-8
• Molecular Formula: C₉H₈BrNO₄
• Molecular Weight: 274.07
• Mol File: 168473-87-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 333.9 °C at 760 mmHg
• Flash Point: 155.7 °C
• Appearance: /
• Density: 1.594 g/cm³
• Vapor Pressure: 0.000133mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 4-BROMO-3-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-BROMO-3-NITROBENZOATE(168473-87-8)
• EPA Substance Registry System: ETHYL 4-BROMO-3-NITROBENZOATE(168473-87-8)

Safety Data

• Hazardous Substances Data: 168473-87-8(Hazardous Substances Data)

Usage

General Description

ETHYL 4-BROMO-3-NITROBENZOATE is a chemical compound with the molecular formula C9H8BrNO4. It is a yellow solid with a molecular weight of 266.07 g/mol. ETHYL 4-BROMO-3-NITROBENZOATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in organic synthesis, particularly in the production of esters and other organic compounds. ETHYL 4-BROMO-3-NITROBENZOATE is considered to be toxic if ingested or inhaled, and it may cause skin irritation upon contact. It should be handled and stored with proper precautions in a well-ventilated area.

InChI:InChI=1/C9H8BrNO4/c1-2-15-9(12)6-3-4-7(10)8(5-6)11(13)14/h3-5H,2H2,1H3

Upstream product

• 5798-75-4 Ethyl 4-bromobenzoate 

Downstream Products

• 861306-79-8 3-nitro-4-phenoxy-benzoic acid ethyl ester 
• 76918-64-4 ethyl 4-amino-3-nitrobenzoate 
• 355425-79-5 4-hydrazino-3-nitro-benzoic acid ethyl ester 
• 100871-16-7 (4-ethoxycarbonyl-2-nitro-phenyl)-cyano-acetic acid ethyl ester 
• 168473-88-9 3-amino-4-bromobenzoic acid ethyl ester 
• 1335114-88-9 C₁₈H₂₄N₂O₈ 
• 78914-77-9 3,3'-azodibenzenemethanol 
• 16588-18-4 ethyl 3-nitro-4-(phenylamino)benzoate 

Relevant articles and documents

The Suzuki–Miyaura Cross-Coupling as the Key Step in the Synthesis of 2-Aminobiphenyls and 2,2'-Diaminobiphenyls: Application in the Synthesis of Schiff Base Complexes of Zn

2-Nitrophenylboronic acids serve as interesting starting materials for the construction of biphenyl- and terphenyl-based amines if subjected to the Suzuki–Miyaura reaction. Unfortunately, these boronic acids suffer from low reactivity in Suzuki reactions, alongside their low stability in the presence of Pd. Herein, a general method for the construction of 2-nitro-substituted bi- and terphenyls is presented, with special emphasis on the synthesis of 2-amino-2'-nitrobi- and terphenyls. Comparisons are made with other boronic acids that have some of the aforementioned issues. Finally, the application of the obtained 2-amino-2'-nitrobi- and terphenyls as starting materials for the synthesis of bi- and terphenyl based di- and triamines is encountered for, with emphasis on the use of these amines as precursors for Schiff base ligands. In addition, the synthesis of some Zn complexes of these ligands is presented.