168560-79-0 Usage
Description
AIDA, also known as a potent and selective group I mGluR agonist, is a chemical compound with white to off-white powder properties. It is utilized in various applications due to its unique properties and functions.
Uses
Used in Pharmaceutical Industry:
AIDA is used as a pharmaceutical agent for its potent and selective agonist properties towards group I mGluR. This makes it a valuable compound in the development of drugs targeting specific receptors, potentially leading to more effective treatments for various conditions.
Used in Research and Development:
In the field of research and development, AIDA serves as a crucial tool for studying the functions and interactions of group I mGluR receptors. Its selective agonist properties allow scientists to investigate the roles these receptors play in cellular processes and signaling pathways, contributing to a deeper understanding of their mechanisms and potential therapeutic applications.
Used in Drug Design and Synthesis:
AIDA's properties as a potent and selective group I mGluR agonist make it a valuable compound in the design and synthesis of new drugs. Its unique interaction with specific receptors can be leveraged to create novel therapeutic agents with improved efficacy and selectivity, potentially leading to better treatment options for patients.
Biological Activity
A relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu 1a ), having no effect on group II (mGlu 2 ) or group III (mGlu 4 ) receptors expressed individually in baby hamster kidney cells. Has no effect on ionotropic glutamate receptors. Centrally active following systemic administration in vivo .
Check Digit Verification of cas no
The CAS Registry Mumber 168560-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,8,5,6 and 0 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 168560-79:
(8*1)+(7*6)+(6*8)+(5*5)+(4*6)+(3*0)+(2*7)+(1*9)=170
170 % 10 = 0
So 168560-79-0 is a valid CAS Registry Number.
168560-79-0Relevant articles and documents
1-Aminoindan-1,5-dicarboxylic Acid: A Novel Antagonist at Phospholipase C-Linked Metabotropic Glutamate Receptors
Pelliciari, Roberto,Luneia, Roberto,Costantino, Gabriele,Marinozzi, Maura,Natalini, Benedetto,et al.
, p. 3717 - 3719 (1995)
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Organocatalytic enantioselective synthesis of metabotropic glutamate receptor ligands
Suri, Jeff T.,Steiner, Derek D.,Barbas III, Carlos F.
, p. 3885 - 3888 (2007/10/03)
(Chemical Equation Presented) (R)-Proline catalyzes the amination reaction of functionalized indane carboxaldehydes and allows for the efficient enantioselective synthesis (>99% ee) of the metabotropic glutamate receptor ligands (S)-AIDA and (S)-APICA.
Asymmetric strecker-type reaction of α-aryl ketones. Synthesis of (S)- αM4CPG, (S)-MPPG, (S)-AIDA, and (S)-APICA, the antagonists of metabotropic glutamate receptors
Ma, Dawei,Tian, Hongqi,Zou, Guixiang
, p. 120 - 125 (2007/10/03)
Heating a mixture of α-aryl ketone with (R)-phenylglycinol produces a mixture of imine and 1,3-dioxazolidine. Treatment of this mixture with trimethylsilyl cyanide followed by transformation of nitrile to ester gives Strecker-type reaction products. The diastereoselectivity of the generated α-amino esters is from 2/1 to 7/1, and the (R,S)isomer is found as the major product. The (R,S) and (R,R)isomers can be separated by conversion to their N-Cbz or cyclization derivatives. Using this methodology, four antagonists of metabotropic glutamate receptors, (S)-αM4CPG, (S)-MPPG, (S)AIDA, and (S)- APICA, are synthesized.
