1689-02-7

Basic information

• Product Name: PYRROLIDINE-1-SULFONYL CHLORIDE
• Synonyms: Albb-005584;pyrrolidine-1-sulfonyl chloride(SALTDATA: FREE);1-PyrrolidinesulfonylChloride
• CAS NO: 1689-02-7
• Molecular Formula: C₄H₈ClNO₂S
• Molecular Weight: 169.63
• Mol File: 1689-02-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 257.5°C at 760 mmHg
• Flash Point: 109.5°C
• Appearance: /
• Density: 1.48g/cm³
• Vapor Pressure: 0.0145mmHg at 25°C
• Refractive Index: 1.542
• PKA: -8.42±0.20(Predicted)
• CAS DataBase Reference: PYRROLIDINE-1-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRROLIDINE-1-SULFONYL CHLORIDE(1689-02-7)
• EPA Substance Registry System: PYRROLIDINE-1-SULFONYL CHLORIDE(1689-02-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1689-02-7(Hazardous Substances Data)

Usage

General Description

PYRROLIDINE-1-SULFONYL CHLORIDE, also known as PSCl, is a chemical compound with the molecular formula C5H8ClNO2S. It is a versatile reagent used in organic synthesis for the preparation of various chemical compounds. PSCl is commonly employed as a reagent for the synthesis of sulfonyl chlorides, which are important intermediates in the pharmaceutical and agrochemical industries. It is also used for the preparation of sulfonamide derivatives, which have applications in medicinal chemistry and drug development. PSCl is a valuable compound for the preparation of diverse chemical products and plays a crucial role in the synthesis of complex organic molecules.

InChI:InChI=1/C4H8ClNO2S/c5-9(7,8)6-3-1-2-4-6/h1-4H2

Upstream product

• 25150-61-2 pyrrolidine hydrochloride 
• 123-75-1 pyrrolidine 

Downstream Products

• 1017-50-1 N-(phenoxysulfonyl)-pyrrolidine 
• 724444-10-4 N-(4-fluorobenzyl)-3-hydroxy-9-[methyl(pyrrolidin-1-ylsulfonyl)amino]-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxamide 
• 1041377-70-1 1-phenyl-2-(pyrrolidin-1-ylsulfonyl)ethan-1-one 

Relevant articles and documents

NEW BRAF INHIBITORS AS PARADOX BREAKERS

The invention provides a novel compound having the general formula (I) (I) wherein R1-R3 and X are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

S(vi) in three-component sulfonamide synthesis: Use of sulfuric chloride as a linchpin in palladium-catalyzed Suzuki-Miyaura coupling

Sulfuric chloride is used as the source of the -SO2- group in a palladium-catalyzed three-component synthesis of sulfonamides. Suzuki-Miyaura coupling between the in situ generated sulfamoyl chlorides and boronic acids gives rise to diverse sulfonamides in moderate to high yields with excellent reaction selectivity. Although this transformation is not workable for primary amines or anilines, the results show high functional group tolerance. With the solving of the desulfonylation problem and utilization of cheap and easily accessible sulfuric chloride as the source of sulfur dioxide, redox-neutral three-component synthesis of sulfonamides is first achieved. This journal is

Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides

The parasitic trypanosomes Trypanosoma brucei and T. cruzi are responsible for significant human suffering in the form of human African trypanosomiasis (HAT) and Chagas disease. Drugs currently available to treat these neglected diseases leave much to be