1689-05-0Relevant articles and documents
Synthesis of novel Azol-β-lactam derivatives starting from phenyl piperazine and investigation of their antiurease activity and antioxidant capacity comparing with their molecular docking studies
Mermer, Arif,Bayrak, Hacer,?irin, Yakup,Emirik, Mustafa,Demirba?, Neslihan
, p. 279 - 287 (2019)
This study reports the synthesis, biological investigation and molecular docking of novel β-lactam derivatives bearing 1,3,4-thiadiazole and 1,3,4-oxadiazole ring system. The synthesized compounds were evaluated for in vitro antiurease activity and antiox
Piperazine-azole-fluoroquinolone hybrids: Conventional and microwave irradiated synthesis, biological activity screening and molecular docking studies
Mermer, Arif,Faiz, Ozlem,Demirbas, Ahmet,Demirbas, Neslihan,Alagumuthu, Manikandan,Arumugam, Sivakumar
, p. 308 - 318 (2019/01/16)
A series of new 1,2,4-triazole and 1,3,4-oxadiazole derivatives was obtained via several steps sequential reactions of phenyl piperazine. Then, these compounds were converted to the corresponding fluoroquinolone hybrids via one pot three component Mannich
PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS
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Paragraph 0091-0092; 0232-0233, (2013/04/24)
The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.