1689-73-2Relevant articles and documents
Redox chemistry, spectroelectrochemistry and catalytic activity of novel synthesized phthalocyanines bearing four schiff bases on the periphery
Karaca, Hüseyin
, p. 39 - 45 (2016)
The synthesis and characterization of novel metallophthalocyanines (M?=?Zn, Co) carrying four schiff base on four peripheral positions were realized. These complexes have been characterized by a combination of FT-IR, 1H NMR, HRMS and UV–Vis spectroscopy t
Synthesis, characterization, and antiproliferative and apoptosis inducing effects of novel: S -triazine derivatives
Shanmugam, Mani,Narayanan, Kuppusamy,Hari Prasad, Kamatam,Karthikeyan, Dhanapalan,Chandrasekaran, Loganathan,Atchudan, Raji,Chidambaranathan
, p. 1698 - 1714 (2018)
In an attempt to design and synthesize a new class of antitumor agents, a mild and eco-friendly protocol for nucleophilic substitution using an s-triazine scaffold, via amine and Schiff base derivatives, has been developed. In order to obtain antitumor activity, all synthesized compounds were screened in vitro for their cytotoxicity against human fibrosarcoma tumor cells (HT-1080) and a cervical cancer cell line (HeLa), for their ability to inhibit the growth of cancer cells. The selected s-triazine analogs (5c, 5d, and 6c) have been preliminarily studied for their reactive oxygen species (ROS) properties, mitochondrial membrane potential (MMP) and apoptosis (AO/EtBr) activity against the HT-1080 cancer cell line. The in vitro anticancer activity analysis has revealed that the synthesized compounds have good/moderate inhibitory activity against the tested cell lines compared to the standard drug. The theoretical study results also provide evidence that the s-triazines scaffolds have been successfully identified as superior p53-MDM2 inhibitors through structure-based design.
Synthesis of novel 8-hydroxyquinoline derivatives through mannich reaction and their biological evaluation as potential immunomodulatory agents
Faizi, Shaheen,Sarfaraz, Tahira,Sumbul, Saima,Jabeen, Almas,Halim, Sobia A.,Mesaik, Mohammad A.,Ul-Haq, Zaheer
, p. 531 - 543 (2020/06/22)
Background: In continuation of our work on Mannich reaction on 8-hydroxyquinoline, fifteen different combinations of aromatic aldehydes and aniline were subjected to Mannich reaction from which twelve products (eight Mannich bases, two imines and two intr
Additional effect of para-hydroxyl on the reduction potentials of the N-benzylidenebenzenamines
Cao, Chao-Tun,Zhou, Wei,Cao, Chenzhong
, (2019/12/27)
The reduction potential ERed of disubstituted N-benzylidenebenzenamines XArCH NArY (abbreviated as XBAY) is a measure of the electron acceptance ability of the Lowest-energy Unoccupied Molecular Orbital (LUMO) in molecule, which is closely related to the electronic effects of substituents X and Y in molecule. Previous studies on the ERed of XBAY reported by Luo, Wang, and Yuan all did not involve these molecules containing hydroxyl. In this work, 28 samples of disubstituted N-benzylidenebenzenamines containing para-hydroxyl, (abbreviated as 4-OHBAY or XBAOH-4′) were synthesized, and their ERed values were measured. Then, 127 compounds were taken as a complicated ERed data set, which involved 28 compounds (4-OHBAY and XBAOH-4′) of this work and 99 compounds XBAY reported by Luo. Based on these data ERed set, through a quantitative regression analysis method and comparison of the factors affecting the ERed, the following results are obtained: (a) Because the phenolic hydroxyl OH can dissociate H+ to form phenolic oxygen anion, the change regularity of ERed of compounds 4-OHBAY and XBAOH-4′ is somewhat different from that of ERed of XBAY compounds without hydroxyl OH. That is, hydroxyl OH has an additional effect on the ERed, which decreases the ERed value. (b) The additional effects of 4-OH on the ERed is different from that of 4′-OH. The effect of hydroxyl OH attached to the aldehyde aromatic ring on the ERed is more than that of OH attached to the amine aromatic ring.
