168902-10-1

Basic information

• Product Name: 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-pentyl ester
• Synonyms: 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl pentyl ester (9CI);MN 9202
• CAS NO: 168902-10-1
• Molecular Formula: C21H26 N2 O6
• Molecular Weight: 402.447
• Mol File: 168902-10-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-pentyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-pentyl ester(168902-10-1)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-methyl 5-pentyl ester(168902-10-1)

Safety Data

• Hazardous Substances Data: 168902-10-1(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 99-61-6 3-nitro-benzaldehyde 
• 49814-16-6 C₉H₁₇NO₂ 
• 39562-17-9 methyl 2-(3-nitrophenylmethylene)acetoacetate 

Relevant articles and documents

Synthesis and antihypertensive activity evaluation in spontaneously hypertensive rats of nitrendipine analogues

The antihypertensive activity of nitrendipine analogues can be improved by properly lengthening its alkyl chain in 3- or 5-position. Nitrendipine and its seven analogues were synthesized, and their antihypertensive activities in spontaneously hypertensive rats (SHR) were evaluated by ig administration. It was found that 5-n-heptyl 3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4- dihydropyridine- 3,5-dicarboxylate [(±)-5] exhibited the strongest antihypertensive effect amongst eight compounds. (?)-5-nheptyl 3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine- 3,5-dicarboxylate [(+)-5] was also prepared. Antihypertensive activities of (±)-5 and (?)-5 in SHR were compared. The results showed that (±)-5 and (?)-5 had a higher potency than nitrendipine, and (+)-isomer was 1.79-fold the raceme at a dose of 2 mg/kg. Springer Science+Business Media, LLC 2010.