16927-82-5

Basic information

• Product Name: (3E)-4-(2-methylphenyl)but-3-en-2-one
• Synonyms: 3-Buten-2-one, 4-(2-methylphenyl)-; 3-Buten-2-one, 4-(2-methylphenyl)-, (3E)-; 4-(2-Methylphenyl)-but-3-en-2-one; Methylbenzylideneacetone
• CAS NO: 16927-82-5
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.2124
• Mol File: 16927-82-5.mol
• Article Data: 31

Chemical Properties

• Boiling Point: 274.3°C at 760 mmHg
• Flash Point: 98.4°C
• Density: 0.999g/cm³
• Vapor Pressure: 0.00546mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: (3E)-4-(2-methylphenyl)but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3E)-4-(2-methylphenyl)but-3-en-2-one(16927-82-5)
• EPA Substance Registry System: (3E)-4-(2-methylphenyl)but-3-en-2-one(16927-82-5)

Safety Data

• Hazardous Substances Data: 16927-82-5(Hazardous Substances Data)

Upstream product

• 89-92-9 2-methylbenzyl bromide 
• 45892-60-2 1-(but-3-en-1-yl)-2-methylbenzene 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 529-20-4 2-methylphenyl aldehyde 
• 52457-01-9 3-Methylcyclohexa-1,4-diene-3-carboxylic acid 
• 78-94-4 methyl vinyl ketone 
• 67-64-1 acetone 
• 1067-71-6 Diethyl (2-oxopropyl)phosphonate 
• 615-37-2 ortho-methylphenyl iodide 
• 2727-71-1 N-(2-bromophenyl)-2,2,2-trifluoroacetamide 
• 292638-85-8 acrylic acid methyl ester 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 57132-23-7 2-Methyl-(3'-hydroxybuten⁽¹⁾-yl)-benzol 
• 57132-25-9 4-(2-methylphenyl)butan-2-one 
• 1293997-20-2 (S)-tert-butyl 2-oxo-5-((S)-3-oxo-1-o-tolylbutyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 1289142-59-1 (R,E)-N-(4-o-tolylbut-3-en-2-yl)benzamide 
• 1289142-87-5 (S,E)-N-(4-o-tolylbut-3-en-2-yl)benzamide 
• 129319-95-5 (E)-4-(o-tolyl)but-3-en-2-amine 
• 1446473-34-2 diethyl 2-hydroxy-4-(2-methoxyphenyl)but-3-en-2-ylphosphonate 
• 1446473-33-1 diethyl 3-oxo-1-phenylbutylphosphonate 
• 1587713-38-9 (Z)-4-(4-(o-tolyl)but-3-en-2-yl)morpholine 
• 1587713-20-9 (E)-4-(4-(o-tolyl)but-3-en-2-yl)morpholine 
• 132294-99-6 (R)-4-hydroxy-3-[1-(2-methylphenyl)-3-oxobutyl]-chromen-2-one 
• 132295-07-9 (S)-4-hydroxy-3-[1-(2-methylphenyl)-3-oxobutyl]-chromen-2-one 

Relevant articles and documents

8-Hydroxyquinolin-2(1H)-one analogues as potential β2-agonists: Design, synthesis and activity study

β2-Agonists that bind to plasmalemmal β2-adrenoceptors causing cAMP accumulation are widely used as bronchodilators in chronic respiratory diseases. Here, we designed and synthesized a group of 8-hydroxyquinolin-2(1H)-one analogues and studied their β2-agonistic activities with a cellular cAMP assay. Compounds B05 and C08 were identified as potent (EC50 2-agonists among the compounds tested. They behaved as partial β2-agonists in non-overexpressed HEK293 cells, and possessed rapid smooth muscle relaxant actions and long duration of action in isolated guinea pig tracheal strip preparations. In summary, B05 and C08 are β2-agonists with potential applicability in chronic respiratory diseases.

Piperlongumine derivative as well as preparation method and application thereof

The invention discloses a Piperlongumine derivative as well as a preparation method and application thereof. The Piperlongumine derivative has the following structure: the Piperlongumine derivative provided by the invention contains a plurality of Michael addition receptor units, and the novel structure improves the electrophilicity, so that the Piperlongumine derivative has good protein targetingpotential, and the Piperlongumine derivative has a good inhibition effect on thioredoxin reductase; in an antitumor bioactive in-vitro screening experiment, the derivative also has a certain inhibition effect on the growth of tumor cells, and meanwhile, the derivative has an effect of promoting the generation of active oxygen in A549 human lung cancer cells.

Chemoselective and metal-free reduction of α,β-unsaturated ketones by: In situ produced benzeneselenol from O -(tert -butyl) Se-phenyl selenocarbonate

The carbon-carbon double bond of arylidene acetones and chalcones can be selectively reduced with benzeneselenol generated in situ by reacting O-(tert-butyl) Se-phenyl selenocarbonate with hydrochloric acid in ethanol. This mild, metal-free and experimentally simple reduction procedure displays considerable functional-group compatibility, products are obtained in good to excellent yields, and the use of toxic Se/CO mixture and NaSeH, or the smelly and air-sensitive benzeneselenol, is avoided. This journal is