1694-92-4

Basic information

• Product Name: 2-Nitrobenzenesulfonyl chloride
• Synonyms: O-NITROBENZENESULFONYL CHLORIDE;2-Nitrobenaenesulfonylchloride;2-nitro-benzenesulfonylchlorid;Benzenesulfonylchloride,2-nitro-;2-NITROBENZENESULFONYL CHLORIDE;2-NITROBENZENESULPHONYL CHLORIDE;1-(Chlorosulfonyl)-2-nitrobenzene;2-Nitro-benzenesulfonyl
• CAS NO: 1694-92-4
• Molecular Formula: C₆H₄ClNO₄S
• Molecular Weight: 221.62
• EINECS: 216-907-1
• Product Categories: Intermediates of Dyes and Pigments;Benzene derivates;Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds;Dyestuff Intermediates
• Mol File: 1694-92-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 63-67 °C(lit.)
• Boiling Point: 350.6 °C at 760 mmHg
• Flash Point: 165.8 °C
• Appearance: Off-white tot yellow crystalline powder
• Density: 1.606 g/cm³
• Vapor Pressure: 8.79E-05mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Store below +30°C.
• Water Solubility: Soluble in toluene, tetrahydrofuran, methylene chloride, ethyl acetate and dimethylformamide. Insoluble in water.
• Sensitive: Moisture Sensitive
• BRN: 521155
• CAS DataBase Reference: 2-Nitrobenzenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitrobenzenesulfonyl chloride(1694-92-4)
• EPA Substance Registry System: 2-Nitrobenzenesulfonyl chloride(1694-92-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• F: 21
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1694-92-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-white tot yellow crystalline powder

Uses

2-Nitrobenzenesulfonyl chloride acts as a reagent to form 2-nitrobenzenesulfonyl derivatives of alcohols and amines. It is also involved in the selective cleavage with thiophenol without displacement of the nitro group. Further, it is used in the preparation of renin inhibitors. In addition to this, it finds application as an anticonvulsant.

InChI:InChI=1/C6H4ClNO4S/c7-13(11,12)6-4-2-1-3-5(6)8(9)10/h1-4H

Upstream product

• 3058-47-7 methyl 2-nitrophenyl sulfide 
• 7732-18-5 water 
• 7782-50-5 chlorine 
• 7669-54-7 2-nitrobenzenesulfenyl chloride 
• 119-66-4 2-nitrobenzenediazonium chloride 
• 22057-44-9 1-(benzylsulfanyl)-2-nitrobenzene 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 88-73-3 2-Chloronitrobenzene 
• 88-74-4 2-nitro-aniline 
• 1155-00-6 bis(2-nitrophenyl)disulfide 
• 7647-01-0 hydrogenchloride 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 137127-87-8 2-nitro-benzenesulfonic acid-[2]pyridylamide 
• 105905-52-0 3-(2-nitro-benzenesulfonylamino)-benzenesulfonyl chloride 
• 17927-91-2 2-(2-nitro-benzenesulfonyl)-benzo[d]isothiazol-3-one 
• 130178-54-0 N-(2-nitrophenylsulphonyl)piperidine-2-carboxylic acid 
• 142529-00-8 2-ethoxycarbonyl-1-(2-nitrobenzenesulfonyl)-1H-pyrrole 
• 25238-19-1 o-Methylphenyl-o-nitrobenzolsulfonat 
• 211512-12-8 N¹,N⁴,N⁸-tris(2-nitrobenzenesulfonyl)-1,8-diamino-4-azaoctane 
• 211512-14-0 1-(2-nitrobenzenesulfonyl)amino-7-aminoheptane 
• 211512-11-7 N¹,N³,N⁶-tris(2-nitrobenzenesulfonyl)-1,6-diamino-3-azahexane 
• 211512-13-9 N-(4-aminobutan-1-yl)-2-nitrobenzenesulfonamide 
• 213611-68-8 (2SR,4R)-4-ethyl-2-methoxy-3-(4-nitrobenzenesulfonyl)-1,3-oxazolidine 

Related news

Oxidative Decarboxylation of Arylacetic Acids Mediated by Peroxysulfur Intermediate Generated from 2-Nitrobenzenesulfonyl chloride (cas 1694-92-4) and Superoxide09/25/2019

The oxidative decarboxylation of aryl, α,α-diaryl, or arylalkylacetic acids has been achieved by a 2-nitrobenzenesulfonyl peroxy radical intermediate (I) generated by the reaction of 2-nitrobenzenesulfonyl chloride with potassium superoxide at -20°C in dry acetonitrile.detailed

Relevant articles and documents

MYELINATION STIMULATOR COMPOUNDS, AND METHODS OF TREATMENT

The invention is directed towards compounds, methods of stimulating myelination, stimulating proliferation of oligodendrocytes (OLs) or stimulating oligodendrocyte precursor cells and methods of treating diseases, disorders or symptoms thereof.

Pharmaceutical intermediates in the synthesis of ortho-nitrophenyl-sulfonyl chloride (by machine translation)

This invention relates to pharmaceutical intermediates in the synthesis of ortho-nitrophenyl-sulfonyl chloride method, comprises the following steps: in the reaction container by adding 5 - hydroxy - 6 - methyl nitrobenzene - sulfur, potassium chloride solution, raising the temperature of the solution, the reaction, then batches and join the trichloro acetic acid solution, the stirring speed is; in time in three batches and adding lauryl carbonyl iron, in raised in temperature, to continue to reaction, the temperature is lowered, separating solid, filtering, for sodium sulfate solution many times, triethylamine solution many times, nonane solution many times, in the alcohol solution to recrystallize, desiccant dehydration, to get finished ortho-nitrophenyl-sulfonyl chloride. (by machine translation)

Aromatic Chlorosulfonylation by Photoredox Catalysis

Visible-light photoredox catalysis enables the efficient synthesis of arenesulfonyl chlorides from anilines. The new protocol involves the convenient in situ preparation of arenediazonium salts (from anilines) and the reactive gases SO2and HCl (from aqueous SOCl2). The photocatalytic chlorosulfonylation operates at mild conditions (room temperature, acetonitrile/water) with low catalyst loading. Various functional groups are tolerated (e.g., halides, azides, nitro groups, CF3, SF5, esters, heteroarenes). Theoretical and experimental studies support a photoredox-catalysis mechanism.