169506-15-4

Basic information

• Product Name: Ethanol, 2-(2-ethoxyphenoxy)-, methanesulfonate
• CAS NO: 169506-15-4
• Molecular Formula: C11H16O5S
• Molecular Weight: 260.311
• Mol File: 169506-15-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanol, 2-(2-ethoxyphenoxy)-, methanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanol, 2-(2-ethoxyphenoxy)-, methanesulfonate(169506-15-4)
• EPA Substance Registry System: Ethanol, 2-(2-ethoxyphenoxy)-, methanesulfonate(169506-15-4)

Safety Data

• Hazardous Substances Data: 169506-15-4(Hazardous Substances Data)

Usage

General Description

Ethanol, 2-(2-ethoxyphenoxy)-, methanesulfonate is a chemical compound that is commonly used as a reagent in organic synthesis. It is also known as O-Methylisourea Methanesulfonate (OMS) and is commonly used as a coupling agent in peptide synthesis. OMS is a crystalline, non-hygroscopic compound that is stable under normal storage conditions. It is used to activate carboxylic acids for amide bond formation and is also used in the preparation of amides, esters, and peptides. Additionally, OMS has been utilized as a methylating agent in the presence of bases.

Upstream product

• 3250-73-5 2-(2-ethoxyphenoxy)ethanol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 106133-20-4 tamsulosin hydrochloride 
• 106133-20-4 (R)-tamsulosin 

Relevant articles and documents

PROCESS FOR PREPARATION OF HIGH PURITY TAMSULOSIN OR SALT THEREOF

The present invention refers to of the existing method contain pharmaceutically available plasticizer manufacturing method compared to a simple, low-environmentally friendly, purity contain pharmaceutically available plasticizer or contain pharmaceutically available plasticizer hydrochloride provides manufacturing method. (by machine translation)

N-Arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective α1-adrenoceptor antagonists

Novel arylpiperazines were identified as α1-adrenoceptor (AR) subtype- selective antagonists by functional in vitro screening. 3-[4-(ortho- Substituted phenyl)piperazin-1:yl]propylamines were derivatized with N,N- dimethyl anthranilamides, nicotinamides, as well as carboxamides of quinoline, 1,8-naphthyridine, pyrazolo[3,4-b]pyridine, isoxazolo[3,4- b]pyridine, imidazo[4,5-b]pyridine, and pyrazolo[1,5-a]pyrimidines. Strips of rabbit bladder neck were employed as a predictive assay for antagonism in the human lower tract. Rings of rat aorta were used as a 'negative screen' for the test antagonists. Binding to α1-ARs was relatively sensitive to size and electronic features of the arylpiperazine portion of the antagonists and permissive to these features on the heteroaryl carboxamide side. These structure-affinity findings were exploited to produce nicotinamides (e.g. 13ii and 25x) and pyrazolo[3,4-b]pyridines (e.g. 37f and 37y) ligands with nanomolar affinity at the α1-AR subtype prevalent in the human lower urinary tract (pA2 values: 8.8, 10.7, 9.3, and 9.9, respectively) and displaying 2-3 orders of magnitude selectivity over the α(1D)-AR.