16966-07-7

Basic information

• Product Name: Z-THR(TBU)-OH DCHA
• Synonyms: Z-THR(TBU)-OH DCHA SALT;Z-THREONINE(TBU)-OH DCHA;Z-T-BUTYL-L-THREONINE DCHA SALT;Z-Thr(tBu)-OH dicyclohexylamine salt;N-benzyloxycarbonyl-O-tert-butyl-L-threonine, compound with dicyclohexylamine;N-Benzyloxycarbonyl-O-tert-butyl-L-threonine dicyclohexylamine;Cbz-DL-Thr(tBu)-OH DCHA;Z-O-tert·butyl-L-threoninedicyclohexylamine salt
• CAS NO: 16966-07-7
• Molecular Formula: C₁₂H₂₃N*C₁₆H₂₃NO₅
• Molecular Weight: 490.68
• EINECS: 241-040-0
• Mol File: 16966-07-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 143-147 °C
• Boiling Point: 636.3 °C at 760 mmHg
• Flash Point: 338.6 °C
• Appearance: /Solid
• Vapor Pressure: 4.58E-17mmHg at 25°C
• Storage Temp.: Store at RT.
• CAS DataBase Reference: Z-THR(TBU)-OH DCHA(CAS DataBase Reference)
• NIST Chemistry Reference: Z-THR(TBU)-OH DCHA(16966-07-7)
• EPA Substance Registry System: Z-THR(TBU)-OH DCHA(16966-07-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 16966-07-7(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C16H23NO5.C12H23N/c1-11(22-16(2,3)4)13(14(18)19)17-15(20)21-10-12-8-6-5-7-9-12;1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h5-9,11,13H,10H2,1-4H3,(H,17,20)(H,18,19);11-13H,1-10H2/t11?,13-;/m0./s1

Upstream product

• 16966-09-9 N-benzyloxycarbonyl-O-t-butyl-L-threonine 
• 101-83-7 N-cyclohexyl-cyclohexanamine 

Downstream Products

• 24205-17-2 Z-Thr(tBu)-Pro-OtBu 
• 41955-11-7 benzyl ((2R)-(3R)-3-(tert-butoxy)-1-hydroxybutan-2-yl)carbamate 
• 52785-41-8 N-benzyloxycarbonyl-O-tert-butylthreonine methyl ester 
• 16966-09-9 N-benzyloxycarbonyl-O-t-butyl-L-threonine 
• 128091-00-9 Z-Asp(OtBu)-Val-Thr(tBu)-Pro-Ser(tBu)-Pro-Thr(tBu)-Pro-OtBu 
• 128090-86-8 Z-Thr(tBu)-Pro-Ser(tBu)-Pro-Thr(tBu)-Pro-OtBu 
• 128090-84-6 Z-Ser(tBu)-Pro-Thr(tBu)-Pro-OtBu 
• 162997-84-4 Z-Thr(t-Bu)-Thr(t-Bu)-O(t-Bu) 

Relevant articles and documents

Efficient and practical procedure for the esterification of the free α-carboxylic acid of amino acid residues with β-(trimethylsilyl)ethoxymethyl chloride and triisopropylsilyl chloride

An efficient and practical procedure for the free α-carboxylic acid esterification of amino acid residues with β-(trimethylsilyl)ethoxymethyl chloride and triisopropylsilyl chloride is described. The reaction takes place under mild conditions and the expected protected amino acids are obtained in good to excellent yields. Our method provides a useful alternative for the C-terminal carboxylic acid protection of amino acids and peptides. Moreover, the removal of such protection was also achieved under mild conditions, without affecting either the other protecting groups at the α-amino moiety and side chains or the optical integrity at the α-position of the amino acid residues. Examples of their use in peptide synthesis are also illustrated.