169689-05-8Relevant articles and documents
2-carbonyl-4-alkyl-4-hydrocarbyl-5-bromine-1,3-oxazine compound and synthesis method thereof
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Paragraph 0043; 0044; 0045, (2017/10/07)
The invention discloses a 2-carbonyl-4-alkyl-4-hydrocarbyl-5-bromine-1,3-oxazine compound and a synthesis method thereof. The structural formula of 2-carbonyl-4-alkyl-4-hydrocarbyl-5-bromine-1,3-oxazine is as shown in formula II, in the formula, R1 is alkyl, aryl or substituted aryl of C1-C5; R2 is alkyl of C1-C5; and Ts refers to toluenesulfonyl. The invention further provides a preparation method of the compound of the formula II. The preparation method comprises the following steps: under the action of scandium trifluoromethanesulfonate, phosphorus oxide ligand and potassium bromide, performing asymmetric halamine cyclization reaction on the compound of the formula I with 1,3-dibromo-5,5-dimethylhydantoin, thereby obtaining the compound. As N-toluenesulfonyl amino allyl ester and dibromo-dimethylhydantoin of different structures of the formula I are adopted as raw materials, under the action of the scandium trifluoromethanesulfonate/phosphorus oxide ligand and the potassium bromide, the 2-carbonyl-4-alkyl-4-hydrocarbyl-5-bromine-1,3-oxazine is effectively synthesized. The preparation method disclosed by the invention is easy in raw material synthesis, gentle in reaction condition, simple and convenient in operation and high in area selectivity, the enantiomer over quantity can be as high as 98%, and the yield is as high as 90%.
A 2-carbonyl-4-olefin-5-bromo -1,3-oxazine and the application of the synthetic method of the compound of (by machine translation)
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Paragraph 0053; 00137, (2017/03/08)
The present invention provides 2-carbonyl-4-olefin-5-bromo -1,3-oxazine compounds and its synthetic method and application. The method comprises: the trifluoromethane sulfonic acid scandium/phosphorus-oxygen ligand and partially under the action of the so
Memory effects in Pd-catalysed allylic alkylation: Stereochemical labelling through isotopic desymmetrization
Lloyd-Jones, Guy C.,Stephen, Susanna C.
, p. 2539 - 2549 (2007/10/03)
2H-Labelled and 18O-labelled cyclopentenyl esters (±)-4 and (±)-5 are used as probes for memory effects in Pd-catalysed allylic alkylation. 2H-Labelled alkylation product 6 arising from stereospecific Pd-catalysed reaction