170489-17-5

Basic information

• Product Name: 4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE
• Synonyms: 4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE;4,7-Dimethoxy-1H-indole-3-carboxaldehyde
• CAS NO: 170489-17-5
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.20994
• Mol File: 170489-17-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE(170489-17-5)
• EPA Substance Registry System: 4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE(170489-17-5)

Safety Data

• Hazardous Substances Data: 170489-17-5(Hazardous Substances Data)

Usage

Description

4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE is a chemical compound with the molecular formula C12H13NO3. It is a derivative of indole and is composed of a benzene ring fused to a five-membered ring containing nitrogen. 4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE is known for its potential biological activities and applications in various fields.

Uses

Used in Pharmaceutical Industry:
4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows it to be a key component in creating various organic compounds with therapeutic potential.
Used in Organic Synthesis:
In the field of organic synthesis, 4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE is used as a chemical reagent to facilitate the creation of complex organic molecules. Its properties make it a valuable asset in the synthesis of a wide range of compounds.
Used in Antifungal and Antibacterial Applications:
4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE has been found to exhibit antifungal and antibacterial properties, making it a potential candidate for use in treatments and products aimed at combating infections caused by fungi and bacteria.
Used in Drug Development:
4,7-DIMETHOXY-1H-INDOLE-3-CARBALDEHYDE has been studied for its potential use in drug development due to its demonstrated biological activities. Researchers are interested in exploring its capabilities in creating new medications to address various health concerns.

Upstream product

• 23876-39-3 4,7-dimethoxylindole 
• 68-12-2 N,N-dimethyl-formamide 
• 1206-55-9 3,6-dimethoxy-2-nitrobenzaldehyde 
• 143814-63-5 (E)-1,4-Dimethoxy-2-nitro-3-(2-nitroethenyl)benzene 

Downstream Products

• 91557-43-6 2-(4,7-dimethoxy-1H-indol-3-yl)ethylamine 
• 220034-71-9 tert-butyl (2-{4,7-dimethoxy-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl}ethyl)carbamate 
• 220034-57-1 tert-butyl (2-{1-[(4-methylphenyl)sulfonyl]-4,7-dioxo-4,7-dihydro-1H-indol-3-yl}ethyl)carbamate 
• 1026325-96-1 2-[4,7-dimethoxy-1-(toluene-4-sulfonyl)-1H-indol-3-yl]ethylamine 
• 892112-74-2 tert-butyl (2-{1-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-7-[(4-methylphenyl)sulfonyl]-4,8-dioxo-1,4,7,8-tetrahydro-pyrrolo[3,2-f]indazol-5-yl}ethyl)carbamate 
• 892113-17-6 tert-butyl (2-{1-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-[(4-methylphenyl)sulfonyl]-4,8-dioxo-1,4,5,8-tetrahydro-pyrrolo[2,3-f]indazol-7-yl}ethyl)carbamate 
• 892113-84-7 7-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one 
• 892113-50-7 9-(3-hydroxy-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-5-[(4-methylphenyl)sulfonyl]-2,3,5,7-tetrahydro-6H-pyrazolo[3,4-h]pyrrolo[4,3,2-de]quinolin-6-one 
• 892113-24-5 5-(toluene-4-sulfonyl)-2,3,5,7-tetrahydro-1,5,7,8-tetraaza-cyclopenta[e]acenaphthylen-6-one 
• 892113-57-4 5-(toluene-4-sulfonyl)-2,3,5,9-tetrahydro-1,5,8,9-tetraaza-cyclopenta[e]acenaphthylen-6-one 
• 892113-63-2 9-methyl-5-[(4-methylphenyl)sulfonyl]-2,3,5,9-tetrahydro-6H-pyrazolo[4,3-h]pyrrolo[4,3,2-de]quinolin-6-one 
• 892113-31-4 7-methyl-5-(toluene-4-sulfonyl)-2,3,5,7-tetrahydro-1,5,7,8-tetraaza-cyclopenta[e]acenaphthylen-6-one 
• 892111-68-1 4,7-dimethoxy-3-(2-nitro-vinyl)-1-(toluene-4-sulfonyl)-1H-indole 

Relevant articles and documents

Methoxycamalexins and related compounds: Syntheses, antifungal activity and inhibition of brassinin oxidase

The phytoalexin camalexin is a competitive inhibitor of brassinin oxidase, an enzyme that detoxifies the phytoalexin brassinin and is produced by an economically important plant pathogen. For this reason, the camalexin scaffold has guided the design of inhibitors of brassinin detoxification. To further understand the structure–activity relationships of camalexin related compounds, the syntheses of monomethoxy and dimethoxycamalexins were undertaken. Four monomethoxy camalexins together with 4,6-dimethoxy and 5,7-dimethoxy camalexins were prepared from the corresponding methoxyindoles using the Ayer's method. The dimethoxy derivatives were prepared from the corresponding dimethoxyindole-3-thiocarboxamides using the Hantzsch reaction; however, this method did not work for the syntheses of 4,6-dimethoxy and 5,7-dimethoxycamalexins due to the lower reactivities of the corresponding indole-3-thiocarboxamides. The antifungal activity and brassinin oxidase inhibitory activity of all methoxycamalexins and ten camalexin related compounds were investigated. Among the 20 compounds evaluated, monomethoxycamalexins were stronger antifungals than the dimethoxy derivatives. However, remarkably, 5,6-dimethoxycamalexin, 6,7-dimethoxycamalexin and 5-methoxycamalexin displayed the strongest inhibitory activity against brassinin oxidase, while 4,5-dimethoxycamalexin displayed no inhibitory effect. Altogether the structure–activity relationships of camalexin related compounds suggest that the targets for fungal growth inhibition and brassinin oxidase inhibition are unrelated and emphasize that brassinin oxidase inhibitors do not need to be antifungal.

Synthesis and antitumor characterization of pyrazolic analogues of the marine pyrroloquinoline alkaloids: Wakayin and tsitsikammamines

A series of aza analogues of the marine alkaloids wakayin and tsitsikammamines A and B have been synthesized. The strategy used was based on [3 + 2] cycloaddition reactions involving 3-ethylamine-indole-4,7-dione and different diazo reagents. All the comp

Propenone derivatives

The present invention relates to propenone derivatives represented by the following formula (I): STR1 wherein R1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR5 (wherein Y represents S or O; and R5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R2 and R3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R2 and R3 are combined to form substituted or unsubstituted methylene or ethylene; R4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.