17061-61-9

Basic information

• Product Name: 4-METHOXYBENZYLAMINE HYDROCHLORIDE
• Synonyms: 4-METHOXYBENZYLAMINE HYDROCHLORIDE;BenzeneMethanaMine, 4-Methoxy- (hydrochloride)(1:1);[[4-Methoxyphenyl]methyl]amine hydrochloride;(4-methoxyphenyl)methanamine hydrochloride
• CAS NO: 17061-61-9
• Molecular Formula: C₈H₁₁NO*ClH
• Molecular Weight: 173.63998
• Mol File: 17061-61-9.mol
• Article Data: 50

Chemical Properties

• Melting Point: 243-244℃
• Boiling Point: 236.5°Cat760mmHg
• Flash Point: 98.8°C
• Appearance: /
• Density: 1.028g/cm³
• CAS DataBase Reference: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(17061-61-9)
• EPA Substance Registry System: 4-METHOXYBENZYLAMINE HYDROCHLORIDE(17061-61-9)

Safety Data

• Hazardous Substances Data: 17061-61-9(Hazardous Substances Data)

Usage

General Description

4-Methoxybenzylamine hydrochloride is a chemical compound derived from benzylamine, which is commonly used in organic synthesis. It is a white solid with a molecular formula of C8H11NO and a molecular weight of 137.18 g/mol. 4-METHOXYBENZYLAMINE HYDROCHLORIDE is often utilized as a reagent in the preparation of various pharmaceuticals and agrochemicals. It is also used as a building block in the synthesis of dyes and pigments. 4-Methoxybenzylamine hydrochloride is known for its role as an intermediate in the production of a wide range of organic compounds and has applications in various industries.

Upstream product

• 874-90-8 4-methoxybenzonitrile 
• 100-07-2 4-methoxy-benzoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 2393-23-9 4-methoxy-benzylamine 
• 1849-02-1 2-chloro-1-methyl-benzimidazole 
• 29559-26-0 (p-methoxyphenyl)nitromethane 
• 3424-93-9 4-methoxyphenylacetamide 
• 1258944-85-2 MeO(C₆H₄)CH₂N(SiMe₂Ph)2 
• 767-00-0 4-cyanophenol 
• 77-78-1 dimethyl sulfate 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 

Downstream Products

• 54582-35-3 p-methoxybenzylurea 
• 56651-60-6 4-methoxybenzyl isocyanate 
• 470690-99-4 [2-mercapto-1-(4-methoxybenzyl)-1H-imidazol-5-yl]methanol 
• 101190-70-9 N₁-(4-methoxybenzyl)-cyanoguanidine 
• 1333500-40-5 7,9-diamino-10-(4'-methoxybenzyl)-6,8,10-triazaspiro[4.5]deca-6,8-diene hydrochloride 
• 1333500-44-9 C₁₆H₂₃N₅O*ClH 
• 1333500-36-9 4,6-diamino-2-ethyl-2-methyl-1,2-dihydro-1-(4'-methoxybenzyl)-1,3,5-triazine hydrochloride 
• 4767-41-3 N₁-(4-methoxy)benzyl biguanide hydrochloride 
• 907972-03-6 C₁₄H₁₇N₅O₂ 
• 1381874-49-2 4-(4-methoxybenzylamino)-2,8-dimethyl-6H-pyrimido[1,2-a]-[1,3,5]triazin-6-one 
• 38164-13-5 1-(4-methoxy-benzyl)-biguanide 
• 1053417-19-8 diethyl 1,4-dihydro-1-(4-methoxybenzyl)-4-phenyl-pyridine-3,5-dicarboxylate 
• 83301-14-8 diethyl 4-(4-methoxylphenyl)-1,4-dihydropyridine-3,5-dicarboxylate 

Relevant articles and documents

Deoxygenative hydroboration of primary, secondary, and tertiary amides: Catalyst-free synthesis of various substituted amines

Transformation of relatively less reactive functional groups under catalyst-free conditions is an interesting aspect and requires a typical protocol. Herein, we report the synthesis of various primary, secondary, and tertiary amines through hydroboration of amides using pinacolborane under catalyst-free and solvent-free conditions. The deoxygenative hydroboration of primary and secondary amides proceeded with excellent conversions. The comparatively less reactive tertiary amides were also converted to the corresponding N,N-diamines in moderate yields under catalyst-free conditions, although alcohols were obtained as a minor product.

Hydrosilylative reduction of primary amides to primary amines catalyzed by a terminal [Ni-OH] complex

A terminal [Ni-OH] complex1, supported by triflamide-functionalized NHC ligands, catalyzes the hydrosilylative reduction of a range of primary amides into primary amines in good to excellent yields under base-free conditions with key functional group tolerance. Catalyst1is also effective for the reduction of a variety of tertiary and secondary amides. In contrast to literature reports, the reactivity of1towards amide reduction follows an inverse trend,i.e., 1° amide > 3° amide > 2° amide. The reaction does not follow a usual dehydration pathway.

Silver-Catalyzed Hydroboration of C-X (X = C, O, N) Multiple Bonds

AgSbF6 was developed as an effective catalyst for the hydroboration of various unsaturated functionalities (nitriles, alkenes, and aldehydes). This atom-economic chemoselective protocol works effectively under low catalyst loading, base- A nd solvent-free moderate conditions. Importantly, this process shows excellent functional group tolerance and compatibility with structurally and electronically diverse substrates (>50 examples). Mechanistic investigations revealed that the reaction proceeds via a radical pathway. Further, the obtained N,N-diborylamines were showcased to be useful precursors for amide synthesis.