171347-80-1

Basic information

• Product Name: (R)-N⁴-Benzyloxy-N¹-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
• Synonyms: (R)-N⁴-Benzyloxy-N¹-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
• CAS NO: 171347-80-1
• Molecular Weight: 478.591
• Mol File: 171347-80-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-N⁴-Benzyloxy-N¹-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N⁴-Benzyloxy-N¹-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide(171347-80-1)
• EPA Substance Registry System: (R)-N⁴-Benzyloxy-N¹-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide(171347-80-1)

Safety Data

• Hazardous Substances Data: 171347-80-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 142880-36-2 galardin 
• 18908-20-8 2-methyl-2-propen-1-yl succinic anhydride 
• 122900-21-4 N^α-Boc-L-tryptophan N-methylamide 
• 142880-34-0 (R)-3-[(S)-2-(1H-Indol-3-yl)-1-methylcarbamoyl-ethylcarbamoyl]-5-methyl-hexanoic acid methyl ester 
• 171347-91-4 (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester 
• 162678-79-7 (2R)-2-[(methoxycarbonyl)methyl]-4-methylpentanoic acid 
• 14035-83-7 dihydro-3-(RS)-(2-methylpropyl)-2,5-furandione 
• 132631-36-8 D,L-2-isobutyl-3-(methoxycarbonyl)-propanoic acid 
• 13139-14-5 Boc-Trp-OH 

Downstream Products

• 142880-36-2 galardin 

Relevant articles and documents

Matrix metalloproteinase inhibitors: A structure-activity study

Modifications around the dipeptide-mimetic core of a hydroxamic acid based matrix metalloproteinase inhibitor were studied. These variations incorporated a variety of natural, unnatural, and synthetic amino acids inaddition to modifications of the P1' and P3' substituents. The results of this study indicate the following structural requirements: (2) Potent inhibitorsmust possess string zinc-binding functionalities. (3) The potential importance of the hydrophobic group at position R3 as illustratedby itsability to impart greater relative potency against stromelysin when larger hydrophobic groups are used. (4) Requirements surrounding the nature of the amino acid appear to be more restrictive for stromelysin than for neutrophil collagenase, 72 kDa gelatinase, and 92 kDa gelatinase. These requirements may involve planar fused-ring aryl systems and possibly hydrogen-bonding capabilities.