17140-81-7

Basic information

• Product Name: Nitrofurantoin1-Hydrate
• Synonyms: Nitrofurantoin1-Hydrate;Nitrofurantoin monohydrate;1-(((5-Nitro-2-furanyl)methylene)amino)-2,4-imidazolidinedione monohydrate;1-(((5-Nitrofuran-2-yl)methylene)amino)-imidazolidine-2,4-dione hydrate
• CAS NO: 17140-81-7
• Molecular Formula: C8H8N4O6
• Molecular Weight: 256.17232
• EINECS: 200-216-7
• Mol File: 17140-81-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.81g/cm³
• Vapor Pressure: 6.57E-10mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Nitrofurantoin1-Hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Nitrofurantoin1-Hydrate(17140-81-7)
• EPA Substance Registry System: Nitrofurantoin1-Hydrate(17140-81-7)

Safety Data

• Hazardous Substances Data: 17140-81-7(Hazardous Substances Data)

Usage

Description

Nitrofurantoin1-Hydrate is an antimicrobial agent that belongs to the nitrofuran class of drugs. It is characterized by its ability to inhibit bacterial growth and is commonly used in the treatment of urinary tract infections. Nitrofurantoin1-Hydrate works by interfering with the bacterial enzymes involved in vital cellular processes, leading to the disruption of bacterial metabolism and ultimately causing cell death.

Uses

Used in Pharmaceutical Industry:
Nitrofurantoin1-Hydrate is used as an anti-infective agent for the treatment of urinary tract infections. It is particularly effective against gram-negative and gram-positive bacteria that commonly cause these infections. The drug's mechanism of action involves the interference with bacterial enzymes, leading to the disruption of bacterial metabolism and cell death.
Used in Diagnostic Applications:
Nitrofurantoin1-Hydrate can be used to diagnose urinary tract infections by identifying the presence of bacteria susceptible to this drug. This helps in determining the appropriate treatment plan for the patient.
Used in Preventive Medicine:
Nitrofurantoin1-Hydrate is also used as a preventive measure to reduce the risk of urinary tract infections, especially in individuals with a history of recurrent infections or those with certain risk factors.
Brand Names:
Some of the brand names under which Nitrofurantoin1-Hydrate is marketed include Furadantin (Procter & Gamble), Furadantin (Sciele), and Furalan (Lannett). These brands are available in various forms such as tablets, capsules, and oral suspensions, making it accessible for different patient needs and preferences.

InChI:InChI=1/C8H6N4O5.H2O/c13-6-4-11(8(14)10-6)9-3-5-1-2-7(17-5)12(15)16;/h1-3H,4H2,(H,10,13,14);1H2/b9-3+;