171550-12-2

Basic information

• Product Name: 4-(4-Hydrazinobenzyl)-2-oxazolidinone
• Synonyms: (S)-4-(4'-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE;(S)-4-(4-AMINOBENZYL)-1,3-OXAZOLIDIN-2-ONE;(S)-4-(4'-AMINOBENZYL)-2-OXAZOLIDINONE;(S)-4-(4-AMINOBENZYL)-2-OXAZOLIDINONE;(S)-4-(4-AMINO-BENZYL)-OXAZOLIDIN-2-ONE;(S)-4-(4-AMINO-BENZYL)-OXAZOLIDINE-2-ONE;4-(4-hydrazinobenzyl)-2-oxazolidinone;4-[(4-hydrazinophenyl)methyl]-2-oxazolidinone
• CAS NO: 171550-12-2
• Molecular Formula: C10H13N3O2
• Molecular Weight: 207.23
• Product Categories: (intermediate of zolmitriptan]
• Mol File: 171550-12-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 107-111 °C
• Boiling Point: 519°C
• Flash Point: 267.891°C
• Appearance: /
• Density: 1.318
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.639
• PKA: 12.65±0.40(Predicted)
• Water Solubility: 0.58 g/L (25 ºC)
• CAS DataBase Reference: 4-(4-Hydrazinobenzyl)-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Hydrazinobenzyl)-2-oxazolidinone(171550-12-2)
• EPA Substance Registry System: 4-(4-Hydrazinobenzyl)-2-oxazolidinone(171550-12-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37
• WGK Germany: 2
• Hazardous Substances Data: 171550-12-2(Hazardous Substances Data)

Usage

General Description

4-(4-Hydrazinobenzyl)-2-oxazolidinone is a chemical compound that is known for its antimicrobial and antitumor properties. It is used in pharmaceutical research as it has shown potential as a novel antibiotic. The compound has also exhibited anti-inflammatory and antioxidant activities, making it a potentially valuable ingredient in the development of new drugs for various medical conditions. Additionally, 4-(4-Hydrazinobenzyl)-2-oxazolidinone has also been studied for its potential use in the treatment of cancer, with promising results in inhibiting the growth of tumor cells. Overall, this compound has shown great potential as a versatile and effective component in the development of pharmaceutical and medical applications.

InChI:InChI=1/C10H13N3O2/c11-13-8-3-1-7(2-4-8)5-9-6-15-10(14)12-9/h1-4,9,13H,5-6,11H2,(H,12,14)

Upstream product

• 152305-23-2 (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one 

Downstream Products

• 139264-57-6 (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride 

Relevant articles and documents

Convenient and industrially viable process for preparation of zolmitriptan

The present invention provides a convenient and industrially viable process for preparation of zolmitriptan. The invention specifically relates to a method for obtaining (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride of desired purity by separation and isolation in a particular pH range to give higher yield and purity.

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF

The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient zolmitriptan. In particular, it relates to an efficient process for the preparation of zolmitriptan and its pharmaceutically acceptable salts and solvates.

N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines

A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.