172226-77-6

Basic information

• Product Name: TERT-BUTYL 2-(2-ETHOXY-2-OXOETHYL)-1H-INDOLE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 2-(2-ETHOXY-2-OXOETHYL)-1H-INDOLE-1-CARBOXYLATE;1H-Indole-2-acetic acid, ethyl ester;2-EthoxycarbonylMethyl-indole-1-carboxylic acid tert-butyl ester
• CAS NO: 172226-77-6
• Molecular Formula: C₁₇H₂₁NO₄
• Molecular Weight: 303.35
• Mol File: 172226-77-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TERT-BUTYL 2-(2-ETHOXY-2-OXOETHYL)-1H-INDOLE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 2-(2-ETHOXY-2-OXOETHYL)-1H-INDOLE-1-CARBOXYLATE(172226-77-6)
• EPA Substance Registry System: TERT-BUTYL 2-(2-ETHOXY-2-OXOETHYL)-1H-INDOLE-1-CARBOXYLATE(172226-77-6)

Safety Data

• Hazardous Substances Data: 172226-77-6(Hazardous Substances Data)

Upstream product

• 33588-64-6 ethyl 2-(1H-indol-2-yl)acetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5344-90-1 2-Aminobenzyl alcohol 
• 78133-84-3 (2-aminobenzyl)triphenylphosphonium bromide 
• 101315-54-2 triphenyl((ethyl(2-carbamoyl)acetate)-2-benzyl)phosphonium bromide 
• 34619-03-9 tert-butyldicarbonate 
• 120-72-9 indole 
• 623-73-4 diazoacetic acid ethyl ester 
• 75400-67-8 indole-1-carboxylic acid tert-butyl ester 

Downstream Products

• 172226-79-8 tert-butyl 2-(2-(ethoxycarbonyl)propan-2-yl)-1H-indole-1-carboxylate 
• 172226-78-7 tert-butyl 2-(1-ethoxy-1-oxopropan-2-yl)-1H-indole-1-carboxylate 

Relevant articles and documents

Enantioselective Syntheses of Strychnos and Chelidonium Alkaloids through Regio- and Stereocontrolled Cooperative Catalysis

We describe enantioselective syntheses of strychnos and chelidonium alkaloids. In the first case, indole acetic acid esters were established as excellent partner nucleophiles for enantioselective cooperative isothiourea/Pd catalyzed α-alkylation. This provides products containing indole-bearing stereocenters in high yield and with excellent levels of enantioinduction in a manner that is notably independent of the N-substituent. This led to concise syntheses of (?)-akuammicine and (?)-strychnine. In the second case, the poor performance of ortho-substituted cinnamyl electrophiles in the enantioselective cooperative isothiourea/Ir catalyzed α-alkylation was overcome by appropriate substituent choice, leading to enantioselective syntheses of (+)-chelidonine, (+)-norchelidonine, and (+)-chelamine.

Palladium-Catalyzed Dearomatizing Difunctionalization of Indoles and Benzofurans

A palladium-catalyzed dearomatizing difunctionalization of N-Boc-indoles and benzofurans to give tricyclic indolines and 2,3-dihydrobenzofurans with a fully substituted carbon center is described. Product formation occurs under mild conditions at room temperature with commercially available aryl boronic acids and 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as a mild oxidant in good yields. 2-Carboxyalkyl-substituted indoles and benzofurans react under Pd-catalysis with aryl boronic acids and TEMPO through dearomatizing arylation/cyclization to the corresponding indolines and dihydrobenzofurans containing a lactone moiety bearing a fully substituted carbon center.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.