172366-38-0

Basic information

• Product Name: 5,7-Difluoro-2-tetralone
• Synonyms: 5,7-DF2T;5,7-DIFLUORO-2-TETRALONE;5,7-DIFLUORO-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;5,7-Difluoro-3,4-dihydro-1H-naphthalen-2-one;7-Difluoro-2-tetralone;5,7-Difluoro-3,4-dihydronaphthalen-2(1H)-one
• CAS NO: 172366-38-0
• Molecular Formula: C10H8F2O
• Molecular Weight: 182.17
• Product Categories: pharmacetical
• Mol File: 172366-38-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 260.58 °C at 760 mmHg
• Flash Point: 99.41 °C
• Appearance: /
• Density: 1.29 g/cm³
• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.523
• CAS DataBase Reference: 5,7-Difluoro-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-Difluoro-2-tetralone(172366-38-0)
• EPA Substance Registry System: 5,7-Difluoro-2-tetralone(172366-38-0)

Safety Data

• Hazardous Substances Data: 172366-38-0(Hazardous Substances Data)

Usage

General Description

5,7-Difluoro-2-tetralone is a chemical compound with the molecular formula C10H6F2O. It is a fluorinated derivative of tetralone, which is a bicyclic aromatic ketone. 5,7-Difluoro-2-tetralone is mainly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential antifungal and antibacterial properties. 5,7-Difluoro-2-tetralone has also been investigated for its potential use in organic electronic materials due to its unique structural and electronic properties. Overall, this compound has potential applications in various industries, including pharmaceuticals and materials science.

InChI:InChI=1/C10H8F2O/c11-7-3-6-4-8(13)1-2-9(6)10(12)5-7/h3,5H,1-2,4H2

Upstream product

• 105184-38-1 3,5-difluorophenyl acetic acid 
• 74-85-1 ethene 
• 157033-24-4 3,5-difluorophenylacetyl chloride 

Downstream Products

• 173996-47-9 (R)-2-amino-5,7-difluoro-1,2,3,4-tetrahydronaphthalene hydrochloride 
• 180914-87-8 (R)-5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine 
• 170151-28-7 (S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine 

Relevant articles and documents

Method for preparing optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine and salts thereof

The invention discloses a method for preparing optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine as shown in formulas a and b and salts thereof. The method comprises the following steps: (1) reacting 3,5-difluorophenylacetic acid with SOCl2 in the presence of a solvent to generate acyl chloride, and then carrying out Friedel-Crafts reaction on the acyl chloride and ethylene under the action of aluminum trichloride; (2) reacting 5,7-difluoro-3,4-dihydronaphthalene-2(1H)-ketone with amide in an organic solvent under an acid catalysis condition, and performing dehydrating to generate enamine; (3) performing catalytic hydrogenation on enamine in the presence of a chiral catalyst to prepare an optically pure intermediate amide; and (4) hydrolyzing the amide under an acidic or alkaline condition to obtain the optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine (a or b) and the form of the salts thereof. The invention provides the method for preparing the optically pure 5,7-difluoro-1,2,3,4-tetrahydronaphthalene-2-amine and salts thereof, which is simple, convenient and easy to industrial production.

METHODS FOR TREATING DEPENDENCE

no abstract published

FUSED RING COMPOUND

A novel compound represented by the general formula (I), and a nematic liquid crystal composition incorporating the same. A compound represented by the general formula (I) can be produced industrially extremely easily, as shown in the examples, displays superior compatibility with current general purpose host liquid crystals as a nematic phase, and also shows little crystal precipitation at low temperatures. Moreover, by addition of a small amount of such a compound to a host liquid crystal, the liquid crystal temperature range at low temperatures can be effectively widened without any significant worsening of the various characteristics of the liquid crystal material. Consequently, a compound of the present invention is an extremely useful liquid crystal material which is suitable for various liquid crystal display elements which require a broad operating temperature range.