173289-76-4Relevant articles and documents
Synthesis of 10(S)-hydroxyeicosatetraenoic acid: A novel cytochrome P-450 metabolite of arachidonic acid
Yeola, Suresh N.,Saleh, Samir A.,Brash, Alan R.,Prakash, Chandra,Taber, Douglass F.,Blair, Ian A.
, p. 838 - 841 (2007/10/03)
10(S)-(-)-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid methyl ester (2) was synthesized in eight steps starting from enantiomerically pure (R)-glyceraldehyde acetonide. The 10(R)-(±)enantiomer was prepared using an identical method except that the starting material was (S)-glyceraldehyde acetonide. By use of these authentic standards, it was possible to confirm that arachidonic acid was converted to a mixture of 10(S)-(-)-hydroxyeicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid (1) and the 10(R)-(+)-enantiomer by phenobarbital-induced rat liver microsomes.
