1733-40-0Relevant articles and documents
INTERMOLEKULARE CC-VERKNUEPFUNG VON AZANICKELACYCLOPENTANONEN, α,ω-DISAEUREAMIDE AUS ALKENEN UND PHENYLISOCYANAT
Hoberg, Heinz,Hernandez, Elisa
, p. 307 - 312 (1986)
The reaction mode of the nickela five-membered ring complexes, prepared from phenyl isocyanate and the alkenes ethene, propene and styrene at (Lig)Ni0 systems, with oxidizing reagents such as FeCl3 and iodine are reported.Depending on the ligan
Amide bond formation in aqueous solution: Direct coupling of metal carboxylate salts with ammonium salts at room temperature
Nielsen, John,Tung, Truong Thanh
supporting information, p. 10073 - 10080 (2021/12/10)
Herein, we report a green, expeditious, and practically simple protocol for direct coupling of carboxylate salts and ammonium salts under ACN/H2O conditions at room temperature without the addition of tertiary amine bases. The water-soluble coupling reagent EDC·HCl is a key component in the reaction. The reaction runs smoothly with unsubstituted/substituted ammonium salts and provides a clean product without column chromatography. Our reaction tolerates both carboxylate (which are unstable in other forms) and amine salts (which are unstable/volatile when present in free form). We believe that the reported method could be used as an alternative and suitable method at the laboratory and industrial scales. This journal is
Catalytic base-controlled regiodivergent heteronucleophilic hydrofunctionalization of β,γ-unsaturated amides
Chen, Rizhi,Du, Qiang,Rui, Jiacheng,Wu, Xiaojin,Zhan, Ying,Zhao, Yao,Zheng, Xintao
supporting information, p. 9756 - 9759 (2021/09/30)
A general catalytic base-controlled regiodivergent nucleophilic hydrofunctionalization of both terminal and internal β,γ-unsaturated amides has been reported. The atom-economical addition of various S/P-based nucleophiles was also exclusively chemoselective. More than 60 branched or linear hetero-substituted aliphatic amides were synthesized from common starting materials under transition-metal-free conditions. Preliminary mechanistic studies are consistent with our proposed divergent catalytic cycles.