173306-82-6

Basic information

• Product Name: 2-TERT-BUTOXYCARBONYLAMINO-PENT-4-YNOIC ACID METHYL ESTER
• Synonyms: 2-TERT-BUTOXYCARBONYLAMINO-PENT-4-YNOIC ACID METHYL ESTER;methyl 2-((tert-butoxycarbonyl)amino)pent-4-ynoate;2-TERT-BUTOXYCARBONYLAMINO-PENT-4-YNOIC ACID METHYL ESTER(WXG02669)
• CAS NO: 173306-82-6
• Molecular Formula: C11H17NO4
• Molecular Weight: 227.26
• Mol File: 173306-82-6.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-TERT-BUTOXYCARBONYLAMINO-PENT-4-YNOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-TERT-BUTOXYCARBONYLAMINO-PENT-4-YNOIC ACID METHYL ESTER(173306-82-6)
• EPA Substance Registry System: 2-TERT-BUTOXYCARBONYLAMINO-PENT-4-YNOIC ACID METHYL ESTER(173306-82-6)

Safety Data

• Hazardous Substances Data: 173306-82-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 3669, 1994 DOI: 10.1016/S0040-4039(00)73067-X

Upstream product

• 67-56-1 methanol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 23235-01-0 (2S)-2-amino-4-pentynoic acid 
• 186581-53-3 diazomethane 
• 61172-66-5 (S)-2-(tert-butoxycarbonylamino)pent-4-ynoic acid 
• 50428-03-0 D,L-propargylglycine 
• 98139-07-2 DL-propargylglycine N-carboxyanhydride 
• 61172-60-9 diethyl α-acetamido-α-propargylmalonate 
• 100394-07-8 2-[[(phenylmethoxy)carbonyl]amino]-4-pentynoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 151139-90-1 (4S)-2,2-dimethyl-4-prop-2'-ynyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 763122-73-2 (2S)-2-tert-butoxycarbonylamino-pent-4-yn-1-ol 
• 101925-55-7 (S)-propargylglycine methyl ester 
• 166271-28-9 (S)-1-methoxy-1-oxopent-4-yn-2-aminium chloride 

Downstream Products

• 1195787-89-3 1-(1,1-dimethylethyl) 2-methyl (2R,5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate 
• 1195787-88-2 methyl (5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-D-prolinate 
• 1195787-87-1 methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-D-prolinate 
• 1195787-85-9 methyl (2R)-2-amino-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-4-pentynoate 
• 1195787-86-0 methyl (2R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate 
• 1195787-75-7 1-(1,1-dimethylethyl) 2-methyl (2S,5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-1,2-pyrrolidinedicarboxylate 
• 1195787-73-5 methyl (5R)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate 
• 1195787-71-3 methyl (5S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-L-prolinate 
• 1195787-70-2 methyl (2S)-5-[5-[(2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl)(methyl)amino]-4-(4-fluoro-2-methylphenyl)-2-pyridinyl]-3,4-dihydro-2H-pyrrole-2-carboxylate 
• 90600-20-7 (2S)-2-[(tert-butoxycarbonyl)amino]pent-4-enoic acid 
• 1261352-21-9 3-[1-(carboxymethyl)-1H-1,2,3-triazol-5-yl]-L-alanine hydrochloride 

Relevant articles and documents

Stereoselective, nonracemic synthesis of ω-borono-α-amino acids

ω-Unsaturated α-amino acids are synthesized through condensation of allyl and propargyl bromides or of 9-bromoundecene with a Ni(II) complex of the Schiff base derived from glycine and BPB. Hydroboration with Ipc2BH followed by oxidation with acetaldehyde affords enantiomerically pure ω- borono-α-aminocarboxylic acids.

Sonogashira Reaction of Bromofluoropyridinaldoxime Nuclei: Convergent Synthesis of Functionalized 2- and 3-Fluoropyridine Scaffolds

A chemoselective palladium catalyzed Sonogashira cross-coupling of bromofluoropyridinaldoxime with highly functionalized alkynes is presented. This reaction is fully compatible with unprotected sensitive aldoxime and affords representative underexplored new scaffolds. The process exhibits a broad scope of alkynes, dialkynes, and large functional group compatibility, including the use of non-radioactive isotopic reporter such as 15N labeled oxime and chiral substrates.

Photoinitiated anti-Hydropentafluorosulfanylation of Terminal Alkynes

A photoinitiated anti-hydropentafluorosulfanylation of terminal alkynes using SF5Cl and (TMS)3SiH as the hydrogen atom donor is reported. This transformation generates selectively (Z)-(1-alken-1-yl)pentafluoro-λ6-sulfanes

Design, synthesis and biological evaluation of C(4) substituted monobactams as antibacterial agents against multidrug-resistant Gram-negative bacteria

A series of novel pyridone conjugated monobactams with various substituents at the (4) position were synthesized and evaluated for their antibacterial activities against a panel of multidrug-resistant (MDR) Gram-negative bacteria in vitro. Compounds 46d, 54 and 75e displayed good to moderate activities against P. aeruginosa, among which the activity of 75e against P. aeruginosa was comparable to that of BAL30072 under iron limitation condition. Compounds 35, 46d, 54, 56a, 56c and 56d exhibited good to excellent antibacterial activities against E. coli and K. pneumoniae, which were comparable or superior to that of BAL30072. In vitro liver microsomal stability was further evaluated and the results manifested that Compounds 35, 46d and 54 were metabolically stable in human liver microsomes.