173340-19-7

Basic information

• Product Name: (1'S, 3S)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINE CARBOXYLIC ACID
• Synonyms: (1'S, 3S)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINE CARBOXYLIC ACID;(1S,3S)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID;(1'S,3S)-1-(1'-Phenylethyl)-5-oxo-pyrrolidinecarboxylicacid;(1''S,3S)-1-(1''-PHENYLETHYL)-5-OXO-PYRROLIDINE CARBOXYLIC ACID 98%;(1'S,3S)-1-(1'-Phenylethyl)-5-oxo-3-pyrrolidine carboxylic acid,98%;(S)-5-Oxo-1-((S)-1-phenylethyl)pyrrolidine-3-carboxylic acid;(1′S,3S)-(?)-1-(1′-Phenylethyl)-5-oxopyrrolidine-3-carboxylic acid ;(3S)-5-oxo-1-[(1S)-1-phenylethyl]pyrrolidine-3-carboxylic acid
• CAS NO: 173340-19-7
• Molecular Formula: C₁₃H₁₅NO₃
• Molecular Weight: 233.26
• Product Categories: organic building block
• Mol File: 173340-19-7.mol
• Article Data: 11

Chemical Properties

• Melting Point: 207-211 °C
• Boiling Point: 460.1°Cat760mmHg
• Flash Point: 232.1°C
• Appearance: white crystalline powder
• Density: g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.48±0.20(Predicted)
• CAS DataBase Reference: (1'S, 3S)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINE CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (1'S, 3S)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINE CARBOXYLIC ACID(173340-19-7)
• EPA Substance Registry System: (1'S, 3S)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINE CARBOXYLIC ACID(173340-19-7)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 24/25-36/37
• WGK Germany: 3
• Hazardous Substances Data: 173340-19-7(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Upstream product

• 97-65-4 2-methylenesuccinic acid 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 188641-35-2 (4S,1'S)-4-hydroxymethyl-1-(1'-phenylethyl)pyrrolidin-2-one 
• 191348-04-6 (S)-3-formylpyrrolidine-1-carboxylic acid t-butyl ester 
• 199174-24-8 tert-butyl (3S)-3-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 174676-79-0 methyl (3R,1'S)-<1-(1'-phenyleth-1'-yl)-pyrrolidin-3-yl> acetate 
• 153566-63-3 (3R)-1-[(1S)-1-phenylethyl]-3-pyrrolidineacetonitrile 
• 508201-49-8 (3S)-1-[(S)-1-phenethyl]-3-(chloromethyl) pyrrolidine 
• 146348-14-3 methyl 5-oxo-1-((S)-1-phenylethyl)pyrrolidine-3-(S)-carboxylate 
• 173724-95-3 (S)-1-((S)-1-phenylethyl)-3-hydroxymethylpyrrolidine 
• 428518-31-4 methyl (S)-(-)-5-oxo-3-pyrrolidinecarboxylate 

Relevant articles and documents

Preparation of novel azabicyclic amines and α7 nicotinic acetylcholine receptor activity of derived aryl amides

(Chemical Equation Presented) Three new azabicyclic amines, namely exo-3-amino-1-azabicyclo[3.2.1]octane, 3-amino-1-azabicyclo-[3.2.2]nonane and exo-6-amino-8-azabicyclo[3.2.1]octane, have been designed and prepared as isosteres of 3-aminoquinuclidine. Ar

1H-PYRAZOLE AND 1H-PYRROLE-AZABICYCLIC COMPOUNDS WITH ALFA-7 NACHR ACTIVITY

The invention provides compounds of Formula (I), wherein Azabicyclo is Formula (I, II, III, IV, V, VI, VII); W is Formula (m); where the variables have the definitions discussed herein. These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals to treat a disease or condition in which α7 is known to be involved.

COMPOUNDS AS RADIOLIGANDS FOR THE DIAGNOSIS OF DISEASE

Radiolabeled ligands useful as probes for determining the relative abundance, receptor occupancy, and/or function of nicotinic acetylcholine receptors. The compounds of Formula I as described herein are labeled with a radioactive isotopic moiety such as 11C, 18F, 76Br, 123I or 125I. Disorders are diagnosed by administering to a mammal a detectably labeled compound and detecting the binding of that compound to the nAChR. The compounds that have been administered are detected using methods including, but not limited to, position emission topography and single-photon to emission computed tomography. The present invention is useful in diagnosing a wide variety of diseases and disorders as discussed herein.