173379-73-2

Basic information

• Product Name: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine
• Synonyms: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine;2,4(1H,3H)-PyriMidinedione, 1-[4-C-azido-2-deoxy-2-fluoro-b-D-arabinofuranosyl]-;4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabino ribofuranosyl uracil;4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine;1-[4-C-Azido-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione;4'-Azido-2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl uracil;4'-C-Azido-2'-deoxy-2'-fluoro-b-D-arabinouridine
• CAS NO: 173379-73-2
• Molecular Formula: C₉H₁₀FN₅O₅
• Molecular Weight: 287.2046032
• EINECS: -0
• Mol File: 173379-73-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine(173379-73-2)
• EPA Substance Registry System: 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine(173379-73-2)

Safety Data

• Hazardous Substances Data: 173379-73-2(Hazardous Substances Data)

Usage

General Description

4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine, also known as FANA, is a modified nucleoside with potential antiviral and antitumor activities. It is a synthetic nucleoside analogue that incorporates an azido group at the 4'-carbon and a 2'-deoxy-2'-fluoro-beta-D-arabinouridine moiety, and is designed to inhibit viral replication and tumor cell growth. 4'-C-azido-2'-deoxy-2'-fluoro-beta-D-arabinouridine has been investigated for its potential in the treatment of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections, as well as various types of cancer. FANA is being studied as a potential therapeutic agent, and research is ongoing to evaluate its safety and efficacy in clinical trials.

Upstream product

• 1145869-37-9 1-(4'-azido-2'-deoxy-3',5'-O-dibenzoyl-2'-fluoro-β-D-arabinofuranosyl)uracil 
• 1333126-30-9 1-(4-azido-2-deoxy-2-fluoro-3-O-benzoyl-5-O-(3-chlorobenzoyl)-β-D-arabinofuranosyl)uracil 

Downstream Products

• 1145869-37-9 1-(4'-azido-2'-deoxy-3',5'-O-dibenzoyl-2'-fluoro-β-D-arabinofuranosyl)uracil 

Relevant articles and documents

Azido nucleosides and nucleotide analogs

Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

Synthesis and biological evaluation of 4-substituted fluoronucleoside analogs for the treatment of hepatitis B virus infection

A series of 4-substituted fluoronucleosides have been synthesized in order to address the toxicity issue of the parent compound 7, and after in vitro evaluation, the cyclopropylamino analog 1f was selected for in vivo study. In mice, this compound exhibit

2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS

Embodiments of the invention are to compounds of formulae (A), (A'), methods, and compositions for use in the treatment of viral infections. More specifically embodiments of the invention aur 2 ', 4 ' -substituted nucleoside compounds useful for the treat