17348-59-3

Basic information

• Product Name: 2-isopropoxy-2-methylpropane
• Synonyms: 2-isopropoxy-2-methylpropane;2-Methyl-2-(1-methylethoxy)propane;tert-Butyl isopropyl ether;Propane, 2-Methyl-2-(1-Methylethoxy)-;t-Butyl isopropyl ether
• CAS NO: 17348-59-3
• Molecular Formula: C₇H₁₆O
• Molecular Weight: 116.20134
• EINECS: 241-373-1
• Product Categories: Aliphatics;Miscellaneous Reagents
• Mol File: 17348-59-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: -95.35°C
• Boiling Point: 87.65°C
• Appearance: /
• Density: 0.7500
• Vapor Pressure: 71.2mmHg at 25°C
• Refractive Index: 1.3891 (estimate)
• Water Solubility: 0.5g/L(25 oC)
• CAS DataBase Reference: 2-isopropoxy-2-methylpropane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isopropoxy-2-methylpropane(17348-59-3)
• EPA Substance Registry System: 2-isopropoxy-2-methylpropane(17348-59-3)

Safety Data

• Hazardous Substances Data: 17348-59-3(Hazardous Substances Data)

Usage

General Description

2-Isopropoxy-2-methylpropane, also known as tert-butyl isopropyl ether, is a chemical compound with the molecular formula C7H16O. It is a colorless, flammable liquid that is commonly used as a solvent in various industrial and laboratory applications. It is also used as a fuel additive, in the production of pharmaceuticals, and as a component in the manufacturing of fragrances and flavors. The chemical is known for its low toxicity and low environmental impact, making it a relatively safe and versatile compound for use in a wide range of industries.

InChI:InChI=1/C7H16O/c1-6(2)8-7(3,4)5/h6H,1-5H3

Upstream product

• 507-20-0 tertiary butyl chloride 
• 67-63-0 isopropyl alcohol 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 17796-75-7 N-(tert-butylthio)phthalimide 
• 683-60-3 sodium isopropylate 
• 345915-09-5 isopropyl N-{5-({[(2S,4S)-1-(tert-butoxycarbonyl)-4-(pyridin-3-ylcarbonyl)thiopyrrolidin-2-yl]methyl}amino)-2-[2-(4-fluorophenyl)ethyl]benzoyl}-L-methioninate 
• 187737-37-7 propene 
• 614-45-9 tert-Butyl peroxybenzoate 
• 920-39-8 isopropylmagnesium bromide 

Downstream Products

• 115-11-7 isobutene 
• 67-64-1 acetone 
• 75-65-0 tert-butyl alcohol 
• 67-63-0 isopropyl alcohol 

Relevant articles and documents

Kinetics and mechanism of N-Boc cleavage: Evidence of a second-order dependence upon acid concentration

The kinetics of the HCl-catalyzed deprotection of the Boc-protected amine, thioester 2 to liberate AZD3409 1 have been studied in a mixture of toluene and propan-2-ol. The reaction rate was found to exhibit a second-order dependence upon the HCl concentration. This behavior was found to have a degree of generality as the deprotection of a second Boc-protected amine, tosylate 3 to yield amine 4 using HCl, sulfuric acid, and methane sulfonic acid showed the same kinetic dependence. In contrast the deprotection of tosylate 3 with trifluoroacetic acid required a large excess of acid to obtain a reasonable rate of reaction and showed an inverse kinetic dependence upon the trifluoroacetate concentration. These observations are rationalized mechanistically in terms of a general acid-catalyzed separation of a reversibly formed ion-molecule pair arising from the fragmentation of the protonated tert-butyl carbamate.

Kinetics of the reactions of tert-butanol with C2-C5 alcohols on sulfo cation exchangers

The kinetics of etherification of tert-butanol with aliphatic alcohols on gel KU-2×8 and macroporous KU-23 sulfo cation exchangers was studied. The first order of reaction with respect to tert-butanol and the -SO3H groups of a catalyst was established. The activation energy of the process observed on KU-2×8 was 60-95 kJ/mol. It was shown that the etherification of tert-butanol on KU-2×8 occurred in a surface layer. The reactivity of primary alcohols introduced into the reaction with tert-butanol increased with their molecular weights (C2-C5). The rate of reaction with secondary alcohols was lower than that with primary alcohols.

The first non-acid catalytic synthesis of tert-butyl ether from tert-butyl alcohol using ionic liquid as dehydrator

Methyl tert-butyl ether (MTBE), ethyl tert-butyl ether (ETBE), and isopropyl tert-butyl ether (IPTBE) have been synthesized for the first time over a non-acid ionic liquid as catalyst and dehydrator with high conversion (> 90%) and selectivity (> 90%) under mild conditions.