17368-12-6Relevant articles and documents
Chemoselective Demethylation of Methoxypyridine
Makino, Kosho,Hasegawa, Yumi,Inoue, Takahide,Araki, Koji,Tabata, Hidetsugu,Oshitari, Tetsuta,Ito, Kiyomi,Natsugari, Hideaki,Takahashi, Hideyo
, p. 951 - 954 (2019/05/10)
A chemoselective demethylation method for various methoxypyridine derivatives has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; no reaction to anisole occurred. The utility of our method was demonstrated by the efficient synthesis of the metabolic substances of the antiulcer agent omeprazole. Chemoselective demethylation at the site of 3,5-dimethyl-4-methoxypyridine in the presence of 4-methoxybenzimidazole was achieved.
IRIDIUM COMPLEX COMPOUNDS, ORGANIC ELECTROLUMINESCENT DEVICES AND USES THEREOF
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Page/Page column 37-38, (2009/03/07)
Blue-emitting phosphorescent compounds show high solubility in solvents for coating solutions in the production of organic EL devices and have excellent thermal stability. Organic EL devices having the blue-emitting phosphorescent compounds have high luminous efficiency and long life. A blue-emitting phosphorescent compound is an iridium complex compound represented by Formula (1) below: wherein R1 is a C2-30 organic group; R2 to R4 are each independently a hydrogen atom or a C1-10 alkyl group; R5 to R8 are each independently an electron-withdrawing group selected from the group consisting of halogen atoms, C1-10 fluorine-substituted alkyl groups, C1-10 fluorine-substituted alkoxy groups, cyano group, aldehyde group, C2-10 acyl groups, C2-10 alkoxycarbonyl groups, C1-10 aminocarbonyl groups, thiocyanate group and C1-10 sulfonyl groups, a C1-10 organic group optionally having a heteroatom (except the electron-withdrawing groups) or a hydrogen atom; and at least one of R5 to R8 is the electron-withdrawing group.
Efficient synthesis of halohydroxypyridines by hydroxydeboronation
Voisin, Anne Sophie,Bouillon, Alexandre,Lancelot, Jean-Charles,Rault, Sylvain
, p. 1417 - 1421 (2007/10/03)
This paper describes a general method for the synthesis of halohydroxypyridines from novel halopyridinylboronic acids and esters recently described by some of us. Halopyridinylboronic acids and esters have been efficiently hydroxydeboronated under mild conditions by employing hydrogen peroxide or meta-chloroperbenzoic acid. These hydroxylations take place regioselectively without other oxidation (N-oxide formation).