17407-37-3

Basic information

• Product Name: DL-ALPHA-TOCOPHEROL HYDROGEN SUCCINATE
• Synonyms: VITAMIN E HYDROGEN SUCCINATE;DL-ALPHA-TOCOPHERYL SUCCINATE;DL-ALPHA-TOCOPHEROL HYDROGEN SUCCINATE;[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl] hydrogen succinate;VITAMIN E SUCCINATE(TOCOPHEROL SUCCINATE)(SECONDARY STANDARD);Butanedioic acid, mono3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl ester;Succinic acid hydrogen 1-[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl] ester;4-keto-4-[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-yl]oxy-butyric acid
• CAS NO: 17407-37-3
• Molecular Formula: C₃₃H₅₄O₅
• Molecular Weight: 530.78
• EINECS: 241-433-7
• Mol File: 17407-37-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 68-71 °C
• Boiling Point: 625.8°Cat760mmHg
• Flash Point: 187°C
• Appearance: /
• Density: 1.002g/cm³
• Vapor Pressure: 1.58E-16mmHg at 25°C
• Refractive Index: 1.498
• PKA: 4.35±0.17(Predicted)
• CAS DataBase Reference: DL-ALPHA-TOCOPHEROL HYDROGEN SUCCINATE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-ALPHA-TOCOPHEROL HYDROGEN SUCCINATE(17407-37-3)
• EPA Substance Registry System: DL-ALPHA-TOCOPHEROL HYDROGEN SUCCINATE(17407-37-3)

Safety Data

• Hazardous Substances Data: 17407-37-3(Hazardous Substances Data)

Usage

Uses

dl-α-Tocopherol Succinate is the racemic analog of α-Tocopheryl Succinate (T539950), a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.

InChI:InChI=1/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)

Upstream product

• 502-69-2 6,10,14-Trimethyl-2-pentadecanon 
• 1117-52-8 6,10,14-trimethyl-5,9,13-pentadecatriene-2-on 
• 505-32-8 isophytol 
• 108-30-5 succinic acid anhydride 
• 59-02-9 vitamin E 

Relevant articles and documents

Covalent and Ionic Conjugates of Trolox and α-Tocopherol with 1-Aminoadamantane

Covalent, ionic, and ionic-covalent conjugates of trolox and α-tocopherol with 1-aminoadamantane were synthesized. Their structures were elucidated using mass spectrometry and IR, PMR, and 13C NMR spectroscopy. The water solubility of the ionic trolox conjugates with 1-aminoadamantane increased by 2–24 times as compared with that of trolox whereas that of the α-tocopherol succinate conjugates remained the same as that of α-tocopherol.

Green preparation method of isoxazole compound participating in water-soluble vitamin E

The invention provides a green synthesis method of an isoxazole compound represented by the formula (III), wherein the aldehyde oxime compound represented by the formula (I) is a substrate and is in an aqueous solution of a surfactant with a mass concentration 1 wt % - 5 wt % in N - chlorosuccinimide. The alkyne compound represented by the formula (II) is reacted 6 - 16h at room temperature under the common action of the basic substance, and the resulting reaction solution is post-treated to obtain the isoxazole compound represented by the formula (III). Water serves as a reaction solvent, the use amount of the organic solvent is reduced, and zero emission of the solvent is realized.

Preparation method for high-purity tocopherol succinate salt

The invention relates to the field of organic synthesis, specifically to a preparation method for tocopherol succinate salt. The preparation method for the tocopherol succinate salt provided by the invention comprises the following steps: hydrogenating dl-alpha-tocopherol in the presence of a precious metal catalyst, subjecting a hydrogenated product and succinic anhydride to an esterification reaction in the presence of alkali so as to prepare a tocopherol succinate intermediate; and subjecting the tocopherol succinate intermediate to salt-forming. The preparation method for the tocopherol succinate salt provided by the invention can effectively improve the purity of a target product, can effectively reduce the content of a single impurity, and can prepare a calcium salt product with a purity capable of reaching 99.9% or above.