174485-30-4Relevant articles and documents
Non-peptidic HIV protease inhibitors: C2-symmetry-based design of bis- sulfonamide dihydropyrones
Janakiraman, Musiri N.,Watenpaugh, Keith D.,Tomich, Paul K.,Chong, Kong-Teck,Turner, Steve R.,Tommasi, Ruben A.,Thaisrivongs, Suvit,Strohbach, Joseph W.
, p. 1237 - 1242 (2007/10/03)
Potent, non-peptidic, dihydropyrone sulfonamide HIV protease inhibitors have been previously described. Crystallographic analysis of dihydropyrone sulfonamide inhibitor/HIV protease complexes suggested incorporation of a second, C2 symmetry-rel