174519-00-7

Basic information

• Product Name: 6-amino-5-(3-chlorocinnamoylamino)-3-propyluracil
• Synonyms: 6-amino-5-(3-chlorocinnamoylamino)-3-propyluracil
• CAS NO: 174519-00-7
• Molecular Weight: 348.789
• Mol File: 174519-00-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-amino-5-(3-chlorocinnamoylamino)-3-propyluracil(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-(3-chlorocinnamoylamino)-3-propyluracil(174519-00-7)
• EPA Substance Registry System: 6-amino-5-(3-chlorocinnamoylamino)-3-propyluracil(174519-00-7)

Safety Data

• Hazardous Substances Data: 174519-00-7(Hazardous Substances Data)

Upstream product

• 1866-38-2 m-Chlorocinnamic acid 
• 142665-13-2 5,6-diamino-3-propyluracil 
• 146830-67-3 6-amino-5-nitroso-3-propyluracil 
• 110472-90-7 6-amino-3-propyluracil 

Downstream Products

• 174519-06-3 (E)-N-(6-Amino-1-methyl-2,4-dioxo-3-propyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3-chloro-phenyl)-acrylamide 
• 174519-12-1 8-[(E)-2-(3-Chloro-phenyl)-vinyl]-3-methyl-1-propyl-3,7-dihydro-purine-2,6-dione 

Relevant articles and documents

A new versatile synthesis of xanthines with variable substituents in the 1-, 3-, 7- and 8-positions

A new convenient procedure for the synthesis of a wide range of xanthines has been developed starting from 3-substituted 6-aminouracils. Nitrosation and reduction yields the corresponding 5,6-diaminouracils, which are condensed with carboxylic acids. The resulting amides can be selectively alkylated at the uracil ring nitrogen N-1 (corresponding to xanthine N-3) under mild conditions. Ring closure and, if desired, alkylation at the 7-position, yields di-, tri-, or tetrasubstituted xanthines in high yields. Sensitive substituents, such as prop-2-ynyl, can be introduced in the 1-position. Variation of the 3-substituent is considerably facilitated in comparison with the standard procedure for the preparation of xanthines.