174626-46-1Relevant articles and documents
Oxindole alkaloids. A novel non-biomimetic entry to (-)-horsfiline
Palmisano, Giovanni,Annunziata, Rita,Papeo, Gianluca,Sisti, Massimo
, p. 1 - 4 (1996)
A novel non-biomimetic synthesis of horsfiline has been developed. The key pyrrolidine forming reaction is the 1,3-dipolar cycloaddition of the thermally generated N-methylazomethine ylide to a suitable 3-akylidene-indolin-2(3H)one. The same strategy was also applied to the synthesis of pure (R)-(-)-enantiomer.