17550-03-7

Basic information

• Product Name: 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-17-beta-ol
• Synonyms: 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-17-beta-ol;19-Norpregna-1,3,5(10)-trien-17-ol, 3-methoxy-, (17alpha)-;Einecs 241-535-1;1,3,5(10)-Estratriene-17a-ethyl-d5-3,17-diol 3-Methyl Ether
• CAS NO: 17550-03-7
• Molecular Formula: C₂₁H₃₀O₂
• Molecular Weight: 314.4617
• EINECS: 241-535-1
• Mol File: 17550-03-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 443.2°Cat760mmHg
• Flash Point: 188.6°C
• Appearance: /
• Density: 1.068g/cm³
• CAS DataBase Reference: 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-17-beta-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-17-beta-ol(17550-03-7)
• EPA Substance Registry System: 3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-17-beta-ol(17550-03-7)

Safety Data

• Hazardous Substances Data: 17550-03-7(Hazardous Substances Data)

Usage

General Description

3-methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-17-beta-ol is a synthetic steroid hormone compound with a chemical formula C21H26O2. It is also known as tibolone and is used in hormone replacement therapy for women experiencing menopausal symptoms. Tibolone has been shown to have estrogenic, progestogenic, and androgenic effects, making it useful in treating symptoms such as hot flashes, vaginal dryness, and osteoporosis. It works by interacting with estrogen, progesterone, and androgen receptors in the body, providing relief from menopausal symptoms and helping to maintain bone density. Despite its benefits, tibolone also carries potential risks and side effects, so it should be used under the supervision of a healthcare professional.

Upstream product

• 72-33-3 mestranol 
• 851-14-9 dl-17α-ethyl-3-methoxyestra-1,3,5(10),8-tetraen-17-ol 
• 1624-62-0 estrone 3-methyl ether 
• 78479-31-9 17α-(E-2-iodovinyl)-Δ^1,3,5-estratrien-3,17β-diol-3 methyl ester 
• 81844-94-2 ((17α,20E)-17-hydroxy-3-methoxy-19-norpregna-1,3,5(10),20-tetraen-21-yl)boronic acid 

Downstream Products

• 52-78-8 norethandrolone 

Relevant articles and documents

Highly Selective Hydrogenation of C═C Bonds Catalyzed by a Rhodium Hydride

Under mild conditions (room temperature, 80 psi of H2) Cp*Rh(2-(2-pyridyl)phenyl)H catalyzes the selective hydrogenation of the C═C bond in α,β-unsaturated carbonyl compounds, including natural product precursors with bulky substituents in the β position and substrates possessing an array of additional functional groups. It also catalyzes the hydrogenation of many isolated double bonds. Mechanistic studies reveal that no radical intermediates are involved, and the catalyst appears to be homogeneous, thereby affording important complementarity to existing protocols for similar hydrogenation processes.

ROMPgel-supported tris(triphenylphosphine)rhodium(I) chloride: A selective hydrogenation catalyst for parallel synthesis

ROMPgel-supported tris(triphenylphosphine)rhodium(I) chloride has been prepared and the immobilised catalyst has been effectively employed in selective hydrogenations of a variety of alkenes and terminal alkynes.

Synthesis of gon-4-enes

1. A therapeutic composition having progestational activity comprising as active ingredient a 17-aliphatic carboxylic acid ester of 17α-ethynyl-18-methyl-19-nortestosterone and a pharmaceutical carrier for said compound.