1759-00-8

Basic information

• Product Name: 2-hydroxy-2-phenyl-N-(pyridin-2-yl)acetamide
• CAS NO: 1759-00-8
• Molecular Weight: 228.25
• Mol File: 1759-00-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2-phenyl-N-(pyridin-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-phenyl-N-(pyridin-2-yl)acetamide(1759-00-8)
• EPA Substance Registry System: 2-hydroxy-2-phenyl-N-(pyridin-2-yl)acetamide(1759-00-8)

Safety Data

• Hazardous Substances Data: 1759-00-8(Hazardous Substances Data)

Upstream product

• 25726-04-9 phenylglyoxylyl chloride 
• 611-73-4 Benzoylformic acid 
• 504-29-0 2-aminopyridine 
• 6337-34-4 2,2-dimethyl-5-phenyl-1,3-dioxolan-4-one 
• 611-71-2 MANDELIC ACID 

Relevant articles and documents

Potassium Phosphate-Catalyzed Chemoselective Reduction of α-Keto Amides: Route to Synthesize Passerini Adducts and 3-Phenyloxindoles

A chemoselective reduction of α-keto amides to biologically important α-hydroxy amides (mandelamides) by polymethylhydrosiloxane (PMHS) using 5 mol% potassium phosphate (K3PO4) as catalyst has been developed. This transition metal-free protocol discloses excellent chemoselectivity for the ketone reduction of α-keto amides in the presence of other reducible functionalities like ketone, nitro, halides, nitrile and amide. Also, the chemoselectively reduced α-hydroxy amide has been derivatized to isocyanide-free Passerini adducts. The N-alkyl-α-hydroxy amides have been successfully converted to 3-phenyloxindole derivatives by treatment with methanesulfonyl cholride and triethylamine.