1768-59-8

Basic information

• Product Name: 1,4-DIPHENYL-3-THIOSEMICARBAZIDE
• Synonyms: diphenylthiosemicarbazide;n,2-diphenyl-hydrazinecarbothioamid;1,4-Diphenylthiosemicarbazide;N,2-Diphenylhydrazinecarbothioamide;1,4-DIPHENYL-3-THIOSEMICARBAZIDE;(E)-N,N-diphenylcarbamohydrazonothioic acid
• CAS NO: 1768-59-8
• Molecular Formula: C₁₃H₁₃N₃S
• Molecular Weight: 243.33
• EINECS: 217-192-9
• Mol File: 1768-59-8.mol
• Article Data: 8

Chemical Properties

• Melting Point: 178°C
• Boiling Point: 366.6 °C at 760 mmHg
• Flash Point: 175.5 °C
• Appearance: /
• Density: 1.304 g/cm³
• Vapor Pressure: 1.45E-05mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1,4-DIPHENYL-3-THIOSEMICARBAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIPHENYL-3-THIOSEMICARBAZIDE(1768-59-8)
• EPA Substance Registry System: 1,4-DIPHENYL-3-THIOSEMICARBAZIDE(1768-59-8)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 1768-59-8(Hazardous Substances Data)

Usage

General Description

1,4-Diphenyl-3-thiosemicarbazide is a chemical compound with the molecular formula C14H14N4S. It is a thiosemicarbazide derivative that is primarily used in the synthesis of organic compounds and coordination chemistry. 1,4-DIPHENYL-3-THIOSEMICARBAZIDE has been studied for its potential applications in the fields of medicinal chemistry, particularly in the development of antitumor and antimicrobial agents. 1,4-Diphenyl-3-thiosemicarbazide has also been investigated for its properties as a corrosion inhibitor and as a ligand for metal complexes in catalytic reactions. Additionally, it has been studied for its potential use in the detection and removal of heavy metal ions from environmental and industrial waste streams.

InChI:InChI=1/C13H13N3S/c17-13(14-11-7-3-1-4-8-11)16-15-12-9-5-2-6-10-12/h1-10,15H,(H2,14,16,17)

Upstream product

• 64-17-5 ethanol 
• 5338-82-9 4-phenyl-5-phenylimino-[1,2,4]dithiazolidin-3-one 
• 100-63-0 phenylhydrazine 
• 103-72-0 phenyl isothiocyanate 
• 7732-18-5 water 
• 13207-47-1 2,4-diphenyl-thiosemicarbazide 
• 108-24-7 acetic anhydride 
• 7647-01-0 hydrogenchloride 
• 409317-81-3 4-phenyl-5-phenylimino-[1,3,4]thiadiazolidin-2-one 
• 62-53-3 aniline 
• 50878-38-1 methyl 2-phenylhydrazinecarbodithioate 
• 71-43-2 benzene 
• 102-08-9 N,N-diphenylthiourea 
• 15989-47-6 1-phenyl-3-guanylthiourea 

Downstream Products

• 861578-73-6 2-phenyl-3-phenylthiocarbamoyl-carbazic acid ethyl ester 
• 50979-38-9 1,3-diphenyl-1,2,3,4-tetrazolium-5-olate 
• 54211-56-2 3-methyl-1,4-diphenyl isothiosemicarbazide 
• 109516-02-1 3,5-dioxo-2-phenyl-pyrazolidine-1-carbothioic acid anilide 
• 645-48-7 1-phenyl-3-thiosemicarbazide 
• 63467-95-8 N,N',3-triphenylcarbazamidine 
• 13136-15-7 1,4-Diphenyl-3-methylmercapto-1,2,4-triazolium iodide 
• 13136-34-0 1-acetyl-1,4-diphenyl thiosemicarbazide 
• 858007-57-5 (5-chloro-5-methyl-4-phenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-phenyl-amine 
• 37761-82-3 5-anilino-2-methyl-3-phenyl-[1,3,4]thiadiazolium; chloride 
• 111271-31-9 (5-chloro-4,5-diphenyl-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-phenyl-amine 
• 110442-37-0 1-benzoyl-1,4-diphenyl thiosemicarbazide 

Relevant articles and documents

Synthesis, in vitro α-glucosidase inhibitory activity and molecular docking studies of new thiazole derivatives

Current study based on the synthesis of new thiazole derivatives via “one pot” multicomponent reaction, evaluation of their in vitro α-glucosidase inhibitory activities, and in silico studies. All synthetic compounds were fully characterized by 1H NMR, 13C NMR and EIMS. CHN analysis was also performed. These newly synthesized compounds showed activities in the range of IC50?=?9.06?±?0.10–82.50?±?1.70?μM as compared to standard acarbose (IC50?=?38.25?±?0.12?μM). It is worth mentioning that most of the compounds such as 1 (IC50?=?23.60?±?0.39?μM), 2 (IC50?=?22.70?±?0.60?μM), 3 (IC50?=?22.40?±?0.32?μM), 4 (IC50?=?26.5?±?0.40?μM), 6 (IC50?=?34.60?±?0.60?μM), 7 (IC50?=?26.20?±?0.43?μM), 8 (IC50?=?14.06?±?0.18?μM), 9 (IC50?=?17.60?±?0.28?μM), 10 (IC50?=?27.16?±?0.41?μM), 11 (IC50?=?19.16?±?0.19?μM), 12 (IC50?=?9.06?±?0.10?μM), 13 (IC50?=?12.80?±?0.21?μM), 14 (IC50?=?11.94?±?0.18?μM), 15 (IC50?=?16.90?±?0.20?μM), 16 (IC50?=?12.60?±?0.14?μM), 17 (IC50?=?16.30?±?0.29?μM), and 18 (IC50?=?32.60?±?0.61?μM) exhibited potent inhibitory potential. Molecular docking study was performed in order to understand the molecular interactions between the molecule and enzyme. Newly identified α-glucosidase inhibitors except few were found to be completely non-toxic.

UV-visible and 1H-15N NMR spectroscopic studies of colorimetric thiosemicarbazide anion sensors

Four model thiosemicarbazide anion chemosensors containing three N-H bonds, substituted with phenyl and/or 4-nitrophenyl units, were synthesised and studied for their anion binding abilities with hydroxide, fluoride, acetate, dihydrogen phosphate and chlo

Synthesis, phytotoxic, cytotoxic, acetylcholinesterase and butrylcholinesterase activities of N,N-diaryl unsymmetrically substituted thioureas

Fourteen N,N-diaryl unsymmetrically substituted thioureas were synthesised and their cytotoxic (in vitro), phytotoxic (in vitro), acetylcholinesterase and butrylcholinesterase activities were determined. Thiourea 16 exhibited high, and 1 and 3 showed significant phytotoxic activity. Thioureas 1, 3, 4, 6 and 10 showed significant activity and 2, 6 and 7 indicated moderate cytotoxic activities. Compound 12 exhibited butrylcholinesterase activity higher than a standard reference.