17735-98-7 Usage
Description
13Z,16Z-Docosadienoic acid is a natural ω-6 polyunsaturated fatty acid (PUFA). It is an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells. This 20:2 PUFA has been identified in mammals, fish, plants, and anaerobic fungi.
Uses
13(Z),16(Z)-Docosadienoic Acid, is a natural polysaturated fatty acid found in mammals, fish, plants, and anaerobic fungi. It is also an agonist of free fatty acid receptor 4 (FFAR4, also known as GPR120) and strongly inhibits the secretion of ghrelin by isolated mouse gastric cells.
references
[1]. x. lu, x. zhao, j. feng, et al. postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through gpr120 in isolated gastric ghrelin cells and mice. am. j. physiol. gastrointest. liver physiol. 303(3), g367-376 (2012). [2]. kimura i. omega-3 fatty acids and ffar4[j]. obesity and diabetes: energy regulation by free fatty acid receptors, 2016: 29.[3]. ma d w l, seo j, switzer k c, et al. n-3 pufa and membrane microdomains: a new frontier in bioactive lipid research[j]. the journal of nutritional biochemistry, 2004, 15(11): 700-706.
Check Digit Verification of cas no
The CAS Registry Mumber 17735-98-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,3 and 5 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17735-98:
(7*1)+(6*7)+(5*7)+(4*3)+(3*5)+(2*9)+(1*8)=137
137 % 10 = 7
So 17735-98-7 is a valid CAS Registry Number.
17735-98-7Relevant articles and documents
Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists
Schiano Moriello, Aniello,López Chinarro, Silvia,Novo Fernández, Olalla,Eras, Jordi,Amodeo, Pietro,Canela-Garayoa, Ramon,Vitale, Rosa Maria,Di Marzo, Vincenzo,De Petrocellis, Luciano
, p. 8255 - 8281 (2018/09/25)
The transient receptor potential vanilloid type-2 (TRPV2) protein is a nonselective Ca2+ permeable channel member of the TRPV subfamily, still considered an orphan TRP channel due to the scarcity of available selective and potent pharmacological tools and endogenous modulators. Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure-activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain fatty acid ethanolamides or primary amides acting as TRPV2 antagonists. Both synthetic and endogenous antagonists exhibited differential inhibition against known TRPV2 agonists characterized by distinct kinetic profiles. These findings represent the first example of both synthetic and naturally occurring TRPV2 modulators with efficacy in the submicromolar/low-micromolar range, which will be useful for clarifying the physiopathological roles of this receptor, its regulation, and its targeting in pathological conditions.
