17737-65-4

Basic information

• Product Name: Clonixin
• Synonyms: 2-[(3-chloro-2-methylphenyl)amino]-3-pyridinecarboxylic acid;CLONIXIC ACID;CLONIXIN;3-Pyridinecarboxylic acid, 2-[(3-chloro-2-methylphenyl)amino]-;CLONIXIC ACID (CLONIXIN);2-(3-CHLORO-2-METHYLPHENYLAMINO)NICOTINIC ACID;2-(3-Chloro-2-methylanilino)pyridine-3-carboxylic acid;2-(3-Chloro-o-toluidino)nicotinic acid
• CAS NO: 17737-65-4
• Molecular Formula: C13H11ClN2O2
• Molecular Weight: 262.69
• EINECS: 241-730-1
• Product Categories: Organics
• Mol File: 17737-65-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 233-235°
• Boiling Point: 410.2 °C at 760 mmHg
• Flash Point: 201.9 °C
• Appearance: white to beige/
• Density: 1.3230 (rough estimate)
• Vapor Pressure: 1.83E-07mmHg at 25°C
• Refractive Index: 1.5270 (estimate)
• Storage Temp.: room temp
• Solubility: DMSO: soluble15mg/mL, clear
• PKA: 1.69±0.36(Predicted)
• Merck: 14,2392
• CAS DataBase Reference: Clonixin(CAS DataBase Reference)
• NIST Chemistry Reference: Clonixin(17737-65-4)
• EPA Substance Registry System: Clonixin(17737-65-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37
• WGK Germany: 3
• RTECS: QT0960000
• Hazardous Substances Data: 17737-65-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 17737-65-4 differently. You can refer to the following data:
1. Analgesic.
2. Clonixin is a non-steroidal anti-inflammatory drug. It also has analgesic, antipyretic, and platelet-inhibitory actions. The compound has been reported to block prostaglandin synthesis, and to block inward calcium currents.

Definition

ChEBI: A pyridinemonocarboxylic acid that is nicotinic acid substituted at position 2 by a (2-methyl-3-chlorophenyl)amino group. Used (as its lysine salt) for treatment of renal colic, muscular pain and moderately severe migraine attacks.

InChI:InChI=1/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)

Upstream product

• 2942-59-8 2-chloronicotinic acid 
• 87-60-5 3-chloro-2-methylbenzenamine 

Downstream Products

• 66898-61-1 2-<(2-metil-3-clorofenil)amino>-3-piridincarboxilato de ftalidilo 
• 127555-46-8 1,3-dihydro-1-(3-chloro-2-methylphenyl)-3-(phenylthio)-2H-pyrrolo[2,3-b]pyridin-2-one 
• 128271-39-6 (3-Chloro-2-methyl-phenyl)-(3-phenylsulfanylmethyl-pyridin-2-yl)-amine 
• 66898-67-7 2-<(2-metil-3-clorofenil)amino>-3-piridincarboxilato de pivaloiloximetilo 

Relevant articles and documents

2-arylamine compound and preparation method and application thereof

The invention discloses a 2-arylamine compound and a preparation method and application thereof. The structure of the 2-arylamine compound is as shown in a formula I shown in the specification, wherein in the formula, the definition of each substituent group is as described in the specification and claims. The compound provided by the invention has a good inhibition effect on fatty acid binding protein 4, and can be used for prevention, treatment or adjuvant treatment of metabolic diseases, inflammations and cancers related to activity or expression of FABP4.

Esters and amides containing the 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl moiety

Compounds of the formula STR1 wherein each X, which may be identical or different from the other X, is oxygen or imino; R1 is hydrogen, fluorine, chlorine or bromine; R2 and R3, which may be identical or different from each other, are each hydrogen; unsubstituted or mono-substituted alkyl of 1 to 6 carbon atoms, where the substituent is phenyl or dialkylamino with 1 to 3 carbon atoms in each alkyl moiety; pyridyl; or cycloalkyl of 5 to 7 carbon atoms; R2 and R3, together with each other and the nitrogen atoms to which they are attached, are pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-aryl-piperazino or N-(alkyl of 1 to 3 carbon atoms)-piperazino; A is cycloalkylene of 5 to 7 carbon atoms; unsubstituted or substituted alkylene of 2 to 10 carbon atoms, where the substituents are one to two alkyls of 1 to 3 carbon atoms each, one to two carbalkoxys of 2 to 4 carbon atoms each, one to two phenyls, one to four hydroxyls, one halomethyl, one hydroxymethyl, one alkanoyloxy of 1 to 18 carbon atoms, one alkanoyloxymethyl of 1 to 18 carbon atoms in the alkanoyl moiety or one STR2 where R1, R2 and R3 have the meanings previously defined; or alkylene of 2 to 10 carbon atoms interrupted by oxygen, sulfur, sulfoxide, sulfonyl, phenyl, cyclohexyl, pyridyl, piperazino or unsubstituted or substituted imino, where the substituent on the imino group is alkyl of 1 to 6 carbon atoms, phenyl or phenylalkyl of 1 to 3 carbon atoms in the alkyl moiety; B is the acyl residue of an antiphlogistic carboxylic acid; and their non-toxic, pharmacologically acceptable acid addition salts. The compounds as well as their salts are useful as anti-inflammatories.