177722-27-9Relevant articles and documents
Highly efficient asymmetric Michael addition reaction of malonates to α,β-unsaturated ketones promoted by a chiral thiourea/PPY dual-catalyst system
Moritaka, Maya,Miyamae, Naomu,Nakano, Keiji,Ichikawa, Yoshiyasu,Kotsuki, Hiyoshizo
, p. 2554 - 2558,5 (2012/12/11)
The enantioselective Michael addition reaction of malonates to α,β-unsaturated ketones is efficiently promoted by a combined dual-catalyst system composed of chiral thiourea and 4-pyrrolidinopyridine (PPY) in toluene. The expected Michael adducts with cyclic and acyclic enones are obtained in excellent yields and with excellent enantioselectivities.
Asymmetric michael addition of malonates to enones catalyzed by a primary Β-amino acid and its lithium salt
Yoshida, Masanori,Narita, Mao,Hara, Shoji
experimental part, p. 8513 - 8517 (2011/12/03)
Highly enantioselective Michael addition of malonates to enones was achieved using a mixed catalyst consisting of a primary Β-amino acid, O-TBDPS (S)-Β-homoserine, and its lithium salt. Various cyclic and acyclic enones were converted into 1,5-ketoesters in high yields (up to 92%) with high enantioselectivity (up to 97% ee) under mild reaction conditions. Details of synthesis of the catalyst, optimization of the reaction conditions for the Michael addition reaction, and a plausible reaction mechanism are described.
Asymmetric induction in Michael addition reactions mediated by C2-symmetric aluminate
Manickam,Sundararajan
, p. 516 - 518 (2007/10/03)
The C2-symmetric chiral amino-diol, (1R, 5R)-3-aza-3- benzyl-1,5-diphenylpentan-1,5-diol (1) is available readily from the reaction of benzylamine with a twofold excess of enantiopure R(+)-styrene epoxide. We have recently shown that the titano
