177748-00-4

Basic information

• Product Name: 7-CHLORO-2-VINYLQUINOLINE
• Synonyms: 7-CHLORO-2-VINYLQUINOLINE;7-chloro-2-ethenylQuinoline
• CAS NO: 177748-00-4
• Molecular Formula: C₁₁H₈ClN
• Molecular Weight: 189.64092
• Mol File: 177748-00-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 305.568 °C at 760 mmHg
• Flash Point: 167.274 °C
• Appearance: /
• Density: 1.226 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.673
• CAS DataBase Reference: 7-CHLORO-2-VINYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-CHLORO-2-VINYLQUINOLINE(177748-00-4)
• EPA Substance Registry System: 7-CHLORO-2-VINYLQUINOLINE(177748-00-4)

Safety Data

• Hazardous Substances Data: 177748-00-4(Hazardous Substances Data)

Usage

Description

7-CHLORO-2-VINYLQUINOLINE, a chlorinated derivative of 2-vinylquinoline with the molecular formula C11H7ClN, is a chemical compound used as an intermediate in the pharmaceutical industry. It is a pale yellow liquid with a pungent odor, insoluble in water but soluble in organic solvents. Known for its potential irritant properties to the skin, eyes, and respiratory system, appropriate safety precautions are necessary during its use and handling.

Uses

Used in Pharmaceutical Industry:
7-CHLORO-2-VINYLQUINOLINE is used as a chemical intermediate for the synthesis of various drugs, contributing to the development of new pharmaceutical products.
Used in Organic Synthesis:
7-CHLORO-2-VINYLQUINOLINE is utilized as a reagent in organic synthesis, enabling the creation of a range of chemical compounds for different applications.
Used in Research and Development:
7-CHLORO-2-VINYLQUINOLINE serves as a valuable compound in research and development, aiding scientists in exploring its properties and potential uses in various fields.

InChI:InChI=1/C11H8ClN/c1-2-10-6-4-8-3-5-9(12)7-11(8)13-10/h2-7H,1H2

Upstream product

• 4965-33-7 2-methyl-7-chloroquinoline 
• 50-00-0 formaldehyd 
• 59394-27-3 7-chloro-quinoline-2-carbaldehyde 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 866923-62-8 2-(1-((((R)-1-(3-((E)-2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)sulfanyl)methyl)cyclopropyl)acetonitrile 
• 158966-92-8 montelukast 
• 151767-02-1 Montelukast sodium 
• 181139-72-0 methyl-[(E)]-2-[3(S)-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl] benzoate 
• 149968-11-6 methyl 2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)benzoate 
• 1258428-71-5 trans-1-{3-[2-(7-chloroquinolin-2-yl)ethenyl]phenyl}-3-[2-(1-hydroxy-1-methylethyl)phenyl]propan-1-one 

Relevant articles and documents

Facile catalyst-free synthesis of 2-vinylquinolines via a direct deamination reaction occurring during Mannich synthesis

A facile catalyst-free method for the synthesis of 2-vinylquinolines via a direct deamination reaction during Mannich synthesis has been developed. Instantaneous hydrogen transfer via a six-membered ring intermediate is proposed as a key step for the direct deamination reaction. This reaction strategy tolerates a broad substrate scope and provides a highly efficient way to synthesize 2-vinylquinolines with adequate yields.

DIBENZOCYCLOHEPTENE COMPOUND

The present invention discloses a dibenzocycloheptene compound represented by the formula (I): ???wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; -CH=CH-, formula; -CH2O-, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc., m: an integer of 1 to 4, n: an integer of 1 to 3, ???------ represents a single bond or a double bond, or a pharmaceutically acceptable salt thereof and a medical composition containing the same as an effective ingredient which has leukotriene C4 antagonistic action and leukotriene E4 antagonistic action in addition to potent leukotriene D4 antagonistic action, and useful as antiasthmatic agent, antiallergic agent and anti-inflammatory agent.