177948-33-3

Basic information

• Product Name: Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate
• Synonyms: Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate;tert-Butyl 4-(1-amino-2-methoxy-2-oxoethyl)
• CAS NO: 177948-33-3
• Molecular Formula: C₁₃H₂₄N₂O₄
• Molecular Weight: 272
• Mol File: 177948-33-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 350.7±12.0 °C(Predicted)
• Appearance: /
• Density: 1.116±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.36±0.50(Predicted)
• CAS DataBase Reference: Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate(177948-33-3)
• EPA Substance Registry System: Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate(177948-33-3)

Safety Data

• Hazardous Substances Data: 177948-33-3(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-2-(1-Boc-4-piperidyl)acetate is a chemical compound with the molecular formula C13H23NO4. It is composed of a methyl group, an amino group, and an acetate group, as well as a piperidyl ring with a Boc (tert-butoxycarbonyl) protecting group attached to the nitrogen atom. Methyl 2-AMino-2-(1-Boc-4-piperidyl)acetate is commonly used as an intermediate in the synthesis of pharmaceuticals, particularly in the production of drugs that target the central nervous system. It is also employed in medical research and as a building block in organic chemical synthesis. Methyl 2-amino-2-(1-Boc-4-piperidyl)acetate is a valuable compound with diverse applications in the pharmaceutical and chemical industries.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 
• 313491-20-2 4-(benzyloxycarbonylamino-methoxycarbonyl-methylene)-piperidine-1-carboxylic acid tert-butyl ester 
• 175213-46-4 1-t-Butoxycarbonyl-4-(methoxycarbonylmethyl)piperidine 
• 1380344-28-4 tert-butyl 4-(1-azido-2-methoxy-2-oxoethyl)piperidine-1-carboxylate 
• 881016-88-2 4-(bromo-methoxycarbonyl-methyl)-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1380344-31-9 C₂₁H₃₀N₄O 
• 1352428-49-9 C₃₀H₃₆N₄O₂ 
• 1352428-50-2 C₃₀H₃₈N₄O₂ 
• 1352428-52-4 C₂₉H₃₆N₄O₂ 
• 1352428-53-5 C₂₈H₃₄N₄O₂ 
• 1352428-54-6 C₂₈H₃₅N₅O₂ 
• 1352428-56-8 C₃₀H₃₅FN₄O₂ 
• 1352428-57-9 C₃₀H₃₅FN₄O₂ 
• 1352428-58-0 C₃₀H₃₅FN₄O₂ 
• 1352428-59-1 C₃₀H₃₅ClN₄O₂ 
• 1352428-60-4 C₃₁H₃₈N₄O₄S 
• 1352428-61-5 C₃₁H₃₅F₃N₄O₂ 
• 1352428-62-6 C₃₁H₃₅F₃N₄O₃ 
• 1352428-63-7 C₃₂H₄₁N₅O₂ 

Relevant articles and documents

Preparation method of 2-amino-2-(1-methyl-4-piperidyl)ethanol

The invention discloses a preparation method of 2-amino-2-(1-methyl-4-piperidyl) ethanol. The preparation method comprises the following steps: reacting 2-methyl-2-propyl-4-(1-amino-2-methoxy-2-oxoethyl)-1-piperidinecarboxylate (a compound II) with benzyl bromide under the action of an alkali 1 to generate a compound III; dissolving the compound III in an organic solvent, and generating a compound IV under the action of a reducing agent; and removing benzyl from the compound IV under the action of a catalyst/hydrogen to generate a compound I.

Compound, pharmaceutically acceptable salt thereof and medical application thereof

The invention belongs to the field of medicines, and particularly relates to a compound shown as a formula I or medicinal salt thereof. The invention also relates to application of the compound or themedicinal salt thereof in selectively inhibiting LF activity, resisting anthrax toxin toxicity and preventing or treating anthracnose.

The discovery of novel cyclohexylamide CCR2 antagonists

As a result of further SAR studies on a piperidinyl piperidine scaffold, we report the discovery of compound 44, a potent, orally bioavailable CCR2 antagonist. While having some in vitro hERG activity, this molecule was clean in an in vivo model of QT pro