177966-65-3 Usage
Description
METHYL (3S)-3-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is a chemical compound with the molecular formula C11H15NO3. It is an amino acid derivative featuring a methyl ester group and a hydroxyphenyl substituent. METHYL (3S)-3-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is known for its structural characteristics and functional groups, which make it a valuable component in the synthesis of pharmaceuticals and other organic compounds.
Uses
Used in Pharmaceutical Synthesis:
METHYL (3S)-3-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and organic compounds.
Used in Drug Development:
In the field of drug development, METHYL (3S)-3-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is utilized as a building block for creating novel therapeutic agents, thanks to its unique structural features and potential biological activity.
Used in Medicinal Chemistry:
METHYL (3S)-3-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE is employed in medicinal chemistry as a compound of interest for further research, given its potential to be integrated into the design and synthesis of new pharmaceutical entities.
Used in Biological Research:
Due to its potential biological activity, METHYL (3S)-3-AMINO-3-(4-HYDROXYPHENYL)PROPANOATE may also be used in biological research to explore its effects and interactions within biological systems, which could lead to new insights and applications in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 177966-65-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,9,6 and 6 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 177966-65:
(8*1)+(7*7)+(6*7)+(5*9)+(4*6)+(3*6)+(2*6)+(1*5)=203
203 % 10 = 3
So 177966-65-3 is a valid CAS Registry Number.
177966-65-3Relevant articles and documents
Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists
Rahman, Md Toufiqur,Decker, Ann M.,Langston, Tiffany L.,Mathews, Kelly M.,Laudermilk, Lucas,Maitra, Rangan,Ma, Weiya,Darcq, Emmanuel,Kieffer, Brigitte L.,Jin, Chunyang
, p. 14989 - 15012 (2020/11/30)
Increasing evidence implicates the orphan G protein-coupled receptor 88 (GPR88) in a number of striatal-associated disorders. In this study, we report the design and synthesis of a series of novel (4-alkoxyphenyl)glycinamides (e.g., 31) and the corresponding 1,3,4-oxadiazole bioisosteres derived from the 2-AMPP scaffold (1) as GPR88 agonists. The 5-amino-1,3,4-oxadiazole derivatives (84, 88-90) had significantly improved potency and lower lipophilicity compared to 2-AMPP. Compound 84 had an EC50 of 59 nM in the GPR88 overexpressing cell-based cAMP assay. In addition, 84 had an EC50 of 942 nM in the [35S]GTPγS binding assay using mouse striatal membranes but was inactive in membranes from GPR88 knockout mice, even at a concentration of 100 μM. In vivo pharmacokinetic testing of 90 in rats revealed that the 5-amino-1,3,4-oxadiazole analogues may have limited brain permeability. Taken together, these results provide the basis for further optimization to develop a suitable agonist to probe GPR88 functions in the brain.
BENZYLAMINE ANALOGUE
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Page/Page column 94, (2008/06/13)
A compound of the formula (I): [wherein R1 represents a C1-C6 alkyl group etc., R2 and R3 are the same or different and represent a hydrogen atom etc., Ra represents a C1-C6 alkyl group etc., Arom represents an aryl group etc., A represents a C1-C6 alkylene group, E represents a single bond, an oxygen atom, a sulfur atom etc., X1 and X2 are the same or different and represent an oxygen atom or a sulfur atom] or a pharmacologically acceptable salt or ester thereof.
