17801-48-8 Usage
Properties
1. Chemical name: 6-chloro-9-(furan-2-ylmethyl)-9H-purine
2. Common name: clofarabine
3. Classification: synthetic antineoplastic agent
4. Mechanism of action: inhibits DNA synthesis and repair, leading to cell death
5. Administration: intravenous
6. Effective in: treatment of various types of cancer, including acute lymphoblastic leukemia
Specific content
1. Belongs to the class of purine nucleoside analogs
2. Prodrug that is rapidly converted to its active form within cells
3. Interferes with DNA and RNA metabolism
4. Shown to be effective in the treatment of pediatric and adult patients with relapsed or refractory leukemia
5. Associated with potential side effects such as myelosuppression, gastrointestinal disturbances, and liver toxicity.
Check Digit Verification of cas no
The CAS Registry Mumber 17801-48-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,8,0 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17801-48:
(7*1)+(6*7)+(5*8)+(4*0)+(3*1)+(2*4)+(1*8)=108
108 % 10 = 8
So 17801-48-8 is a valid CAS Registry Number.
17801-48-8Relevant articles and documents
6-(Alkylamino)-9-benzyl-9H-purines. A New Class of Anticonvulsant Agents
Kelley, James L.,Krochmal, Mark P.,Linn, James A.,McLean, Ed W.,Soroko, Francis E.
, p. 606 - 612 (2007/10/02)
Several 9-alkyl-6-substituted-purines were synthesized and tested for anticonvulsant activity against maximal electroshock-induced seizures (MES) in rats.Most compounds were prepared in three steps from 5-amino-4,6-dichloropyrimidine or in two steps via alkylation of 6-chloropurine.Potent anticonvulsant activity against MES resided in compounds that contain a benzyl substituent at the 9-position of 6-(methylamino)- or 6-(dimethylamino)purine.Among commonly used agents for control of seizures, this type of structure represents a new class of potent anticonvulsant agents.
