178306-50-8

Basic information

• Product Name: (+/-)-methyl 2-hydroxy-3,3-diphenylbutanoate
• Synonyms: (+/-)-methyl 2-hydroxy-3,3-diphenylbutanoate
• CAS NO: 178306-50-8
• Molecular Weight: 270.328
• Mol File: 178306-50-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (+/-)-methyl 2-hydroxy-3,3-diphenylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-methyl 2-hydroxy-3,3-diphenylbutanoate(178306-50-8)
• EPA Substance Registry System: (+/-)-methyl 2-hydroxy-3,3-diphenylbutanoate(178306-50-8)

Safety Data

• Hazardous Substances Data: 178306-50-8(Hazardous Substances Data)

Upstream product

• 76527-25-8 3,3-diphenyloxirane-2-carboxylic acid methyl ester 
• 75-24-1 trimethylaluminum 
• 917-54-4 methyllithium 
• 119-61-9 benzophenone 
• 67-56-1 methanol 
• 197971-84-9 2-hydroxy-3,3-diphenylbutyronitrile 

Downstream Products

• 1349685-25-1 (R)-methyl 2-hydroxy-3,3-diphenylbutanoate 
• 1349685-27-3 (S)-methyl 3,3-diphenyl-2-propylaminocarbonyloxybutanoate 
• 318472-14-9 (S)-2-(4,6-dimethylpyrimid-2-yloxy)-3,3-diphenylbutyricacid 
• 197971-87-2 2-hydroxy-3,3-diphenylbutyric acid 

Relevant articles and documents

New carboxylic acid derivative, its production and its use

Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.

Method of producing 2-hydroxycarboxylic acid esters

A process for preparing 2-hydroxycarboxylic esters having a quaternary β-carbon atom by reaction of glycidyl esters with an organoaluminum reagent is described.

Carboxylic acid derivatives, their preparation and use in treating cancer

This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of Formula I or Formula Ia, as describe herein.