178551-26-3

Basic information

• Product Name: 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide
• Synonyms: 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide
• CAS NO: 178551-26-3
• Molecular Weight: 452.348
• Mol File: 178551-26-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide(178551-26-3)
• EPA Substance Registry System: 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide(178551-26-3)

Safety Data

• Hazardous Substances Data: 178551-26-3(Hazardous Substances Data)

Upstream product

• 2107-69-9 5,6-dimethoxy-1-indanone 
• 223397-73-7 Br^(1-)*C₁₃H₁₂NO⁽¹⁺⁾ 
• 4803-74-1 5,6-dimethoxy-2-[(pyridin-4-yl)methylene]-1-indanone 
• 100-39-0 benzyl bromide 

Downstream Products

• 142057-77-0 donepezil hydrochloride 
• 923571-20-4 C₂₄H₂₅NO₃ 

Relevant articles and documents

A PROCESS FOR PREPARATION OF INTERMEDIATES OF DONEPEZIL HYDROCHLORIDE

The present invention provides a process for the preparation of key intermediate for the synthesis 5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1-indanone hydrochloride (donepezil hydrochloride). The present invention particularly provides a process for the preparation of 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone comprising condensation of 5,6-dimethoxy-1-indanone with 4- pyridinecarboxaldehyde using an alkali metal hydroxide as a mild base in the presence of demineralized water as a solvent at a temperature in the range of 15°C to 45°C to yield 5,6-dimethoxy-2-(4-pyridylmethylene)-1-indanone, which is subsequently benzylated using benzyl bromide in the presence of solvent at a reflux temperature to yield 1-benzyl-4-[(5,6-dimethoxy-1-indanone-2-yl)methylene]pyridinium bromide.