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17857-14-6

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17857-14-6 Usage

Chemical Properties

White powder and granules

Uses

Different sources of media describe the Uses of 17857-14-6 differently. You can refer to the following data:
1. suzuki reaction
2. (3-Carboxypropyl)triphenylphosphonium bromide is used as antimalarial agents, antimycobacterial agents,antifungal agents, inhibitors of protein tyrosine phosphatase.
3. (3-Carboxypropyl)triphenylphosphonium Bromide is a reagent used in the preparation of sphingosine 1-phosphate-1 receptor antagonists. Also used in the synthesis of mitochondrial vitamin E metabolites and other mitochondrial targets in the study of mitochodrial functions. Also used in the preparation of benzosuberene analogs that inhibit tubulin assembly and demonstrate cytotoxicity.

Check Digit Verification of cas no

The CAS Registry Mumber 17857-14-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,8,5 and 7 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 17857-14:
(7*1)+(6*7)+(5*8)+(4*5)+(3*7)+(2*1)+(1*4)=136
136 % 10 = 6
So 17857-14-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H21O2P.BrH/c23-22(24)17-10-18-25(19-11-4-1-5-12-19,20-13-6-2-7-14-20)21-15-8-3-9-16-21;/h1-9,11-16H,10,17-18H2;1H

17857-14-6 Well-known Company Product Price

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  • (Code)Product description
  • CAS number
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  • Price
  • Detail
  • TCI America

  • (C1635)  (3-Carboxypropyl)triphenylphosphonium Bromide  >95.0%(HPLC)(T)

  • 17857-14-6

  • 25g

  • 540.00CNY

  • Detail
  • Alfa Aesar

  • (A19302)  (3-Carboxypropyl)triphenylphosphonium bromide, 97%   

  • 17857-14-6

  • 25g

  • 647.0CNY

  • Detail
  • Alfa Aesar

  • (A19302)  (3-Carboxypropyl)triphenylphosphonium bromide, 97%   

  • 17857-14-6

  • 100g

  • 1854.0CNY

  • Detail
  • Alfa Aesar

  • (A19302)  (3-Carboxypropyl)triphenylphosphonium bromide, 97%   

  • 17857-14-6

  • 500g

  • 7449.0CNY

  • Detail
  • Aldrich

  • (349720)  (3-Carboxypropyl)triphenylphosphoniumbromide  98%

  • 17857-14-6

  • 349720-25G

  • 694.98CNY

  • Detail
  • Aldrich

  • (349720)  (3-Carboxypropyl)triphenylphosphoniumbromide  98%

  • 17857-14-6

  • 349720-100G

  • 1,987.83CNY

  • Detail

17857-14-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-carboxypropyl(triphenyl)phosphanium,bromide

1.2 Other means of identification

Product number -
Other names (4-Hydroxy-4-oxobutyl)triphenylphosphonium bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17857-14-6 SDS

17857-14-6Relevant articles and documents

Enantiospecific synthesis of L-α-aminosuberic acid. Synthetic applications in preparation of atrial natriuretic factor analogues

Wernic,DiMaio,Adams

, p. 4224 - 4228 (1989)

-

5-(2-methylphenyl)-4-pentenoic acid from a terrestrial Streptomycete

Mukku, Venugopal J. R. V.,Maskey, Rajendra P.,Monecke, Peter,Grün-Wollny, Iris,Laatsch, Hartmut

, p. 335 - 337 (2002)

From a terrestrial Streptomycete, GW 10/2517, the new 5-(2-methylphenyl)-4-pentenoic acid (1a) was isolated. The structure of 1a was proven by a detailed spectroscopic analysis and by synthesis.

Stepwise dual targeting and dual responsive polymer micelles for mitochondrion therapy

Wang, Yi,Wei, Guoqing,Yang, Guang,Zhang, Xiaobin,Zhao, Jingya,Zhou, Shaobing

, p. 157 - 169 (2020)

Methods to selectively destroy mitochondria of tumor cells and induce cell apoptosis with nanomedicine constitute challenges in cancer therapy. In the present study, we develop cell membrane/mitochondria dual targeting and pH/redox dual responsive nanoparticles for mitochondrion therapy. The nanoparticles are fabricated by the self-assembly of triphenylphosphonium (TPP) grafted poly(ethylene glycol)(PEG)-poly(d,L-lactide)(PLA) copolymers (TPP-PEG-ss-PLA) using disulfide bonds as the intermediate linkers. To shield the surface positive charge of the nanoparticles from TPP composition, chondroitin sulfate (CS) is employed to coat the nanoparticles, and this prolongs blood circulation while endowing an active targeting ability to the cell membrane. In acidic lyso-somes/endosomes, the negatively charged CS layer falls away to expose the TPP component. Subsequently, in the cyto-plasm, the nanoparticles can anchor to the mitochondrial outer membrane by TPP-mediated targeting, thereby inducing a decrease in the membrane potential and opening of the permeability transition pore. Thus, the overproduction of ROS in the mitochondria promotes cell apoptosis. The released DOX directly diffuse into the mitochondria, thereby resulting in mito-chondrial DNA damage. Therefore, the nanoparticles exhibit significant potential in terms of a new avenue for mitochondrion therapy in cancer treatment.

CANNABINOIDS AND USES THEREOF

-

Page/Page column 122, (2021/06/11)

The invention relates to cannabinoid compounds, pharmaceutical compositions including one or more cannabinoid compounds, and the use of pharmaceutical compositions including one or more cannabinoid compounds for the treatment of a disease or condition (e.

Mitochondrial targeting neuroprotective medicine TPP-QT as well as preparation method and application thereof

-

Paragraph 0032, (2021/10/27)

The invention belongs to the field of biopharmacy and relates to a nerve protection drug, in particular to a mitochondria-targeted nerve protection drug TPP-QT as well as a preparation method and application thereof. Its structural formula is: QT And TPP

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