1786-81-8 Usage
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 1786-81-8 differently. You can refer to the following data:
1. antibacterial
2. Propitocaine hydrochloride is a local anesthetic of the amino amide type,it is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.
3. Anesthetic (local).
Definition
ChEBI: The monohydrochloride salt of prilocaine.
Brand name
Citanest (AstraZeneca).
Biological Functions
Prilocaine hydrochloride (Citanest) is an amide
anesthetic whose onset of action is slightly longer than
that of lidocaine; its duration of action is comparable.
Prilocaine is 40% less toxic acutely than lidocaine, making
it especially suitable for regional anesthetic techniques.
It is metabolized by the liver to orthotoluidine,
which when it accumulates, can cause conversion of hemoglobin
(HB+++ to methemoglobin (HB+++. Oxygen
transport is impaired in the presence of methemoglobinemia.
Treatment involves the use of reducing agents,
such as methylene blue, given intravenously, to reconvert
methemoglobin to hemoglobin.
Contact allergens
Prilocaine in a local anesthetic of the amide group. It
can induce allergic contact dermatitis, particularly
from EMLA? cream.
Check Digit Verification of cas no
The CAS Registry Mumber 1786-81-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,8 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1786-81:
(6*1)+(5*7)+(4*8)+(3*6)+(2*8)+(1*1)=108
108 % 10 = 8
So 1786-81-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H20N2O.ClH/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2;/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);1H
1786-81-8Relevant articles and documents
A method for preparing prilocaine hydrochloride
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Paragraph 0054, (2017/03/14)
The invention relates to a synthetic process of anesthetic, in particular to a method for preparing propitocaine hydrochloride. The method includes the following steps that a, ortho-toluidine is added into dichloromethane, alpha-propionyl chloride is dropwise added at the room temperature, and the reaction lasts for 2-3 h at the temperature of 15 DEG C-25 DEG C, acid solution washing is performed on the obtained reaction liquid, then, aqueous alkali washing is performed on the obtained reaction liquid, water is added to an organic layer to separate solids out, and then propitocaine hydrochloride midbody is obtained through filtration; b, the propitocaine hydrochloride midbody obtained in the step a is added into n-propylamine, reflux is heated for 5-7 h, after the reaction is ended, concentrated hydrochloric acid is added to adjust the PH to be 1-2, white solids are separated out and are refined through ethyl alcohol of 95%, and therefore the propitocaine hydrochloride is obtained. An acetone solvent which is unfriendly to the environment and has hypotoxicity in a traditional method is replaced by the commonly used solvent dichloromethane which is basically free of toxic, and therefore environment-friendly industrial mass production becomes possible on the premise of not affecting the yield.
