178608-00-9

Basic information

• Product Name: (2S*,3R*,4S*)-4-(1,3-Benzodioxol-5-yl)-1-(N,N-dibutylcarbamoylmethyl)-2-pentylpyrrolidine-3-carboxylic acid
• CAS NO: 178608-00-9
• Molecular Formula: C₂₇H₄₂N₂O₅
• Molecular Weight: 474.64619
• Mol File: 178608-00-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2S*,3R*,4S*)-4-(1,3-Benzodioxol-5-yl)-1-(N,N-dibutylcarbamoylmethyl)-2-pentylpyrrolidine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S*,3R*,4S*)-4-(1,3-Benzodioxol-5-yl)-1-(N,N-dibutylcarbamoylmethyl)-2-pentylpyrrolidine-3-carboxylic acid(178608-00-9)
• EPA Substance Registry System: (2S*,3R*,4S*)-4-(1,3-Benzodioxol-5-yl)-1-(N,N-dibutylcarbamoylmethyl)-2-pentylpyrrolidine-3-carboxylic acid(178608-00-9)

Safety Data

• Hazardous Substances Data: 178608-00-9(Hazardous Substances Data)

Upstream product

• 10488-95-6 ethyl 3-oxooctanoate 
• 212480-17-6 2-(1-Benzo[1,3]dioxol-5-yl-2-nitro-ethyl)-3-oxo-octanoic acid ethyl ester 
• 195707-98-3 methyl 2-(4-hexenoyl)-4-nitro-3-(1,3-benzodioxole-5-yl)butyrate 
• 239098-37-4 4-benzo[1,3]dioxol-5-yl-2-pentyl-4,5-dihydro-3H-pyrrole-3-carboxylic acid methyl ester 
• 220584-64-5 methyl trans,trans-2-(pentyl)-4-(1,3-benzodioxol-5-yl)pyrrolidine-3-carboxylate 
• 110874-83-4 methyl 3-oxo-6-octenoate 
• 1485-00-3 5-((E)-2-nitroethenyl)-1,3-benzodioxole 

Relevant articles and documents

Endothelin antagonists

A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ET(A) antagonist (A-216546)

Previously we have reported the discovery of ABT-627 (1, A-147627, active enantiomer of A-127722), a 2,4-diaryl substituted pyrrolidine-3- carboxylic acid based endothelin receptor-A antagonist. This compound binds to the ET(A) receptor with an affinity (

ENDOTHELIN ANTAGONISTS

A compound of the formula (I): STR1 or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.