17886-71-4

Basic information

• Product Name: 2-benzylidene-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3(2H)-one
• CAS NO: 17886-71-4
• Molecular Formula: C₁₂H₁₀N₂OS
• Molecular Weight: 230.2856
• Mol File: 17886-71-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 381.9°C at 760 mmHg
• Flash Point: 184.8°C
• Density: 1.37g/cm³
• Vapor Pressure: 4.91E-06mmHg at 25°C
• Refractive Index: 1.715
• CAS DataBase Reference: 2-benzylidene-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzylidene-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3(2H)-one(17886-71-4)
• EPA Substance Registry System: 2-benzylidene-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3(2H)-one(17886-71-4)

Safety Data

• Hazardous Substances Data: 17886-71-4(Hazardous Substances Data)

Upstream product

• 96-45-7 N,N'-ethylenethiourea 
• 100-52-7 benzaldehyde 
• 79-11-8 chloroacetic acid 
• 105-39-5 chloroacetic acid ethyl ester 
• 19951-23-6 2-((4,5-dihydro-1H-imidazol-2-yl)thio)acetic acid 
• 96-45-7 4,5-dihydro-1H-imidazole-2-thiol 
• 6703-51-1 5,6-dihydro-imidazo[2,1-b]thiazol-3-one 
• 92114-17-5 (4,5-dihydro-1H-imidazol-2-ylsulfanyl)-thioacetic acid S-(4,5-dihydro-1H-imidazol-2-yl) ester 
• 91774-37-7 ethyl [(4,5-dihydro-2-imidazolyl)thio]acetate hydrochloride 

Downstream Products

• 108651-20-3 3-(2-amino-ethyl)-5-benzylidene-thiazolidine-2,4-dione; hydrochloride 
• 1389252-37-2 3-phenyl-2,3,6,7-tetrahydroimidazo[2,1-b]thiazolo[5,4-d]isoxazole 
• 137017-07-3 3-Phenyl-3,3a,6,7-tetrahydro-2H-imidazo[2,1-b]pyrazolo[3,4-d]thiazole 

Relevant articles and documents

Synthesis of some novel fused imidazo [2, 1-b] [1, 3] thiazole and imidazo [2, 1-b] thiazolo [5, 4-d] isoxazole derivatives

In this work we describe the synthesis of some novel fused imidazo [2, 1-b] [1, 3] thiazole derivatives. The reaction of 1, 2-diaminoethane 1 with carbon disulphide in H2O/ETOH as solvent furnishes 4, 5-dihydro-1H-imidazol- 2-thiol 2 under reflux condition. the reaction of 4, 5-dihydro-1H-imidazol-2- thiol on treatment with ethylchloro acetate and aromatic aldehyde in presence of anhydrous sodium acetate and acetic acid as solvent to give (Z)-2- (arylidene)-5, 6-dihydroimidazo [2, 1-b] [1, 3] thiazol-3 (2H)-one 3a-j. Compounds 3a-j was condensed with hydroxylamine to give 3- (aryl)-2, 3, 6, 7-tetrahydroimidazo [2, 1-b] [1, 3] thiazolo [5, 4-d] isoxazole 4a-j. The structures of the new compounds were established by elemental analyses, IR, 1H NMR and 13C NMR data.

Novel bridgehead nitrogen heterocycles: Synthesis and antimicrobial activity of 2H-imidazopyrazolothiazoles

Synthesis of 3-substituted 3,3a,6,7-tetrahydro-2H-imidazopyrazolothiazoles (IIIa) and their 2-phenyl derivatives (IIIb) have been achieved in a single step by treating 2-arylidene-5,6-dihydroimidazothiazolidin-3-ones (II) with hydrazine and phenylhydrazine, respectively.Compounds II in turn have been obtained by condensing 2-mercaptoimidazoline with ethyl chloroacetate and aldehydes in the presence of pyridine and piperidine.Compounds III constitute a novel and hitherto unknown heterocyclic system.The antibacterial and antifungal activities of IIIa and IIIb have also been determined.