178896-76-9 Usage
Ester derivative of pyrrolopyridine carboxylic acid
This compound is derived from pyrrolopyridine carboxylic acid by the addition of an ethoxy group, making it an ester.
Building block in the synthesis of pharmaceuticals and agrochemicals
1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid, ethyl ester is commonly used as a starting material in the synthesis of various drugs and pesticides.
Versatile intermediate in organic chemistry
This compound is often used as an intermediate in the preparation of different heterocyclic compounds, making it a valuable tool in organic synthesis.
Valuable tool for the development of new drug candidates
Due to its unique structure and reactivity, 1H-Pyrrolo[3,2-b]pyridine-3-carboxylic acid, ethyl ester is useful in the development of new drugs and other biologically active molecules.
Employed in the production of fine chemicals and as a research reagent
This compound is also used in the production of specialized chemicals and as a reagent in both chemical and biological research.
Check Digit Verification of cas no
The CAS Registry Mumber 178896-76-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,8,9 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 178896-76:
(8*1)+(7*7)+(6*8)+(5*8)+(4*9)+(3*6)+(2*7)+(1*6)=219
219 % 10 = 9
So 178896-76-9 is a valid CAS Registry Number.
178896-76-9Relevant articles and documents
Lead optimization of 1,4-azaindoles as antimycobacterial agents
Shirude, Pravin S.,Shandil, Radha K.,Manjunatha,Sadler, Claire,Panda, Manoranjan,Panduga, Vijender,Reddy, Jitendar,Saralaya, Ramanatha,Nanduri, Robert,Ambady, Anisha,Ravishankar, Sudha,Sambandamurthy, Vasan K.,Humnabadkar, Vaishali,Jena, Lalit K.,Suresh, Rudrapatna S.,Srivastava, Abhishek,Prabhakar,Whiteaker, James,McLaughlin, Robert E.,Sharma, Sreevalli,Cooper, Christopher B.,Mdluli, Khisi,Butler, Scott,Iyer, Pravin S.,Narayanan, Shridhar,Chatterji, Monalisa
, p. 5728 - 5737 (2014/08/05)
In a previous report, we described the discovery of 1,4-azaindoles, a chemical series with excellent in vitro and in vivo antimycobacterial potency through noncovalent inhibition of decaprenylphosphoryl-β-d-ribose-2′- epimerase (DprE1). Nevertheless, high mouse metabolic turnover and phosphodiesterase 6 (PDE6) off-target activity limited its advancement. Herein, we report lead optimization of this series, culminating in potent, metabolically stable compounds that have a robust pharmacokinetic profile without any PDE6 liability. Furthermore, we demonstrate efficacy for 1,4-azaindoles in a rat chronic TB infection model. We believe that compounds from the 1,4-azaindole series are suitable for in vivo combination and safety studies.