178977-57-6Relevant articles and documents
Synthesis and cytotoxicity studies of new cryptophycin analogues
Wen, Lu Liu,Jian, Cun Zhang,Fa, Qin Jiang,Fu, Lei
experimental part, p. 577 - 583 (2009/12/24)
Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC50 values in the μM-range, and compound 4 was more effective than compound 3 in most assays studied.
Total synthesis of cryptophycin 3
Danner, Paulami,Bauer, Matthias,Phukan, Prodeep,Maier, Martin E.
, p. 317 - 325 (2007/10/03)
The depsipeptide cryptophycin 3 (5) and the cryptophycin analogue 43 were prepared from the corresponding four subunits, The tripeptide analogue 34 was acquired from the starting amino ester 33, which contains fragments D and C. After extension at the car
Total Synthesis of Cryptophycins-1, -3, -4, -24 (Arenastatin A), and -29, Cytotoxic Depsipeptides from Cyanobacteria of the Nostocaceae
White, James D.,Hong, Jian,Robarge, Lonnie A.
, p. 6206 - 6216 (2007/10/03)
A convergent synthesis of cryptophycins has been developed in which (5S,6R)-5-hydroxy-6-methyl-8-phenylocta-2(E),7(E)-dienoic acid (A) is coupled with an amino acid segment (B). Two stereo-selective routes to A are described, the first employing allylatio
