17900-11-7 Usage
Quinoline derivative
It is a chemical compound derived from the quinoline structure, which is a tricyclic aromatic compound with a core structure of two fused benzene rings and one azole ring.
Fluoroquinolone antibiotics
This compound belongs to the class of fluoroquinolone antibiotics, which are a group of synthetic antimicrobial agents that inhibit bacterial DNA replication and transcription.
Antimicrobial properties
2-(4-chlorophenyl)-6-fluoroquinoline-4-carboxylic acid has potential antimicrobial properties, making it effective against a variety of microorganisms.
Pharmaceutical industry application
It is used in the pharmaceutical industry for the synthesis of novel antibiotics, contributing to the development of new and improved antibacterial drugs.
Chlorine and fluorine atoms
The presence of a chlorine and a fluorine atom attached to the quinoline ring gives this compound unique chemical and biological properties, which may enhance its antimicrobial activity.
Carboxylic acid group
The presence of a carboxylic acid group in its structure allows for easy modification and optimization of its pharmacological activity, potentially leading to more effective and targeted treatments.
Potential applications
2-(4-chlorophenyl)-6-fluoroquinoline-4-carboxylic acid has potential applications in the development of new and improved antibacterial drugs, addressing the growing concern of antibiotic resistance and the need for novel treatment options.
Check Digit Verification of cas no
The CAS Registry Mumber 17900-11-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,9,0 and 0 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 17900-11:
(7*1)+(6*7)+(5*9)+(4*0)+(3*0)+(2*1)+(1*1)=97
97 % 10 = 7
So 17900-11-7 is a valid CAS Registry Number.
17900-11-7Relevant articles and documents
A green synthesis of quinoline-4-carboxylic derivatives using p-toluenesulfonic acid as an efficient organocatalyst under microwave irradiation and their docking, molecular dynamics, ADME-Tox and biological evaluation
Patel, Dhaval B.,Patel, Hitesh D.,Rajani, Dhanji P.,Rajani, Smita D.
, (2020/02/27)
P-Toluenesulfonic acid, being an efficient, nonhazardous, and fast accessible organocatalyst, was used for the preparation of quinoline-4-carboxylic acid derivatives via a one-pot three-component reaction of aromatic benzaldehyde, substituted aniline, and pyruvic acid under microwave irradiation. After completion of the reaction, the pure products were isolated by column chromatography. Here, to achieve the desired synthesis, various catalytic and solvent conditions were applied to perform a comparison study. We are using higher yield, simple work-up process, avoiding the use of hazardous organic solvents, short reaction time and higher advantages of the present protocol in the study. Biological activities of synthesized compounds were tested against various antibacterial, antifungal, antimalarial, and antituberculosis strains. Compounds 4a and 4c (MIC 50 μg/mL) and compounds 4d and 4n (MIC 62.5 μg/mL) were found active against the Escherichia coli strain, compounds 4c and 4p (MIC 25 μg/mL) were found active against the Staphylococcus aureus strain, and compounds 4c and 4d were found active against the Plasmodium falciparum strain. Molecular docking revealed that ligands and proteins fitted exactly in the binding pocket and had significant correlation with the biological activity. We have also tested molecular dynamics and ADME-Tox parameters for the synthesized compounds.
