179110-53-3

Basic information

• Product Name: 1H-Pyrazole-3-carboxylic acid, 4-bromo-5-phenyl-, ethyl ester
• CAS NO: 179110-53-3
• Molecular Formula: C12H11BrN2O2
• Molecular Weight: 295.136
• Mol File: 179110-53-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-3-carboxylic acid, 4-bromo-5-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylic acid, 4-bromo-5-phenyl-, ethyl ester(179110-53-3)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylic acid, 4-bromo-5-phenyl-, ethyl ester(179110-53-3)

Safety Data

• Hazardous Substances Data: 179110-53-3(Hazardous Substances Data)

Upstream product

• 6296-54-4 ethyl 2,4-dioxo-4-phenylbutyrate 
• 13599-12-7 ethyl 3-phenyl-1H-pyrazole-5-carboxylate 

Downstream Products

• 291758-01-5 4-(6-chloro-benzo[1,3]dioxol-5-ylmethyl)-2-(3-methoxy-benzyl)-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 291758-00-4 4-benzo[1,3]dioxol-5-ylmethyl-2-(3-methoxy-benzyl)-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 291757-98-7 4-bromo-2-(3-methoxy-benzyl)-5-phenyl-2H-pyrazole-3-carboxylic acid ethyl ester 

Relevant articles and documents

Nonpeptide endothelin antagonists: From lower affinity pyrazol-5-ols to higher affinity pyrazole-5-carboxylic acids

Random screening of compounds in endothelin receptor (ET(A) and ET(B)) binding assays led to the discovery of a new class of pyrazol-5-ol ligands. Characterization of structural features crucial for binding activities of these pyrazol-5-ols, by structure-activity-relationship (SAR) studies, allowed us to design a novel class of pyrazole-5-carboxylic acids as more potent ET antagonists. (C) 2000 Elsevier Science Ltd. All rights reserved.