179321-49-4

Basic information

• Product Name: 4-N-Boc-aminocyclohexanone
• Synonyms: BOC-4-AMINOCYCLOHEXANONE;(4-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER;4-N-BOC-AMINOCYCLOHEXANONE;4-N-BOC-4-AMINOCYCLOHEXANONE;4-AMINOCYCLOHEXANONE N-BOC PROTECTED;N-4-BOC-AMINOCYCLOHEXANONE;N-T-BOC-4-AMINOCYCLOHEXANONE;TERT-BUTYL 4-OXOCYCLOHEXYLCARBAMATE
• CAS NO: 179321-49-4
• Molecular Formula: C₁₁H₁₉NO₃
• Molecular Weight: 213.27
• EINECS: 1806241-263-5
• Product Categories: N-BOC;Amines;blocks;Acids and Derivatives;Carbonyl Compounds;pharmacetical;CHIRAL CHEMICALS;Building Blocks;C10 to C11;C11 to C12;Chemical Synthesis;Ethers;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Oxygen Compounds
• Mol File: 179321-49-4.mol
• Article Data: 23

Chemical Properties

• Melting Point: 114-118℃
• Boiling Point: 335.9 °C at 760 mmHg
• Flash Point: 157 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.000116mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 12.19±0.20(Predicted)
• CAS DataBase Reference: 4-N-Boc-aminocyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-Boc-aminocyclohexanone(179321-49-4)
• EPA Substance Registry System: 4-N-Boc-aminocyclohexanone(179321-49-4)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36/37/38-50
• Safety Statements: 26-36/37/39-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 179321-49-4(Hazardous Substances Data)

Usage

General Description

4-N-Boc-aminocyclohexanone is a chemical compound with the molecular formula C13H23NO3. It is a derivative of cyclohexanone, with a Boc-protected amino group attached to the fourth carbon atom. 4-N-Boc-aminocyclohexanone is commonly used in the synthesis of pharmaceuticals and organic compounds. The Boc protecting group is often employed to prevent unwanted reactions with the amino group during chemical transformations, allowing for selective modification of the molecule. 4-N-Boc-aminocyclohexanone has been used in the synthesis of various bioactive compounds, making it a valuable intermediate in organic chemistry.

InChI:InChI=1/C11H19NO3/c1-11(2,3)15-10(14)12-8-4-6-9(13)7-5-8/h8H,4-7H2,1-3H3,(H,12,14)

Upstream product

• 27489-62-9 trans-4-hydroxycyclohexylamine 
• 224309-64-2 tert-butyl N-(4-hydroxycyclohexyl)carbamate 
• 79-37-8 oxalyl dichloride 
• 114615-82-6 tetrapropylammonium perruthennate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 50910-54-8 trans-4-aminocyclohexanol hydrochloride 
• 7529-22-8 4-methylmorpholine N-oxide 
• 27489-62-9 trans-4-aminocyclohexan-1-ol 
• 34619-03-9 tert-butyldicarbonate 
• 87976-86-1 4‐aminocyclohexanone 
• 87413-09-0 Dess-Martin periodane 
• 6850-65-3 p-hydroxycyclohexylamine 
• 111300-06-2 trans-tert-butyl 4-hydroxycyclohexylcarbamate 

Downstream Products

• 87976-86-1 4‐aminocyclohexanone 
• 847956-42-7 (4-tert-Butylamino-cyclohexyl)-carbamic acid tert-butyl ester 
• 615568-43-9 4-((tert-butoxycarbonyl)amino)cyclohex-1-ene-1-carboxylic acid 
• 886206-14-0 C₂₄H₃₈FN₃O₃ 
• 886206-16-2 C₂₃H₃₃F₄N₃O₃ 
• 412293-53-9 N'-benzyl-N-tert-butoxy-carbonyl-N'-methyl-trans-1,4-cyclohexanediamine 
• 233764-31-3 tert-butyl N-(4-hydroxy-4-methylcyclohexyl)carbamate 
• 725255-70-9 tert-butyl (4-methylenecyclohexyl)carbamate 
• 1248730-88-2 benzyl 4-[4-(tert-butoxycarbonylamino)cyclohexyl]piperazine-1-carboxylate 
• 1437123-12-0 tert-butyl (4-(9-nitro-5,6-dihydro-2H-imidazo[2,1-b][1,3,6]oxadiazocin-4(3H)-yl)cyclohexyl)carbamate 
• 886206-12-8 C₂₁H₃₃N₃O₃ 
• 233764-31-3 (cis-1,4)-(4-hydroxy-4-methyl-cyclohexyl)carbamic acid tert-butyl ester 
• 233764-31-3 tert-butyl (trans-4-hydroxy-4-methylcyclohexyl)carbamate 
• 675112-40-0 4-aminocyclohexan-1-one hydrochloride 

Relevant articles and documents

Novel Compounds as Autotaxin Inhibitors and Pharmaceutical Compositions Comprising the Same

The present invention relates to a novel autotaxin inhibitor compound for preventing and treating disease or symptoms due to an increase in concentration of lysophosphatidic acid or activation of autotaxin. The present invention further relates to a pharmaceutical composition containing the same. The novel compound of the present invention is an autotaxin inhibitor which inhibits production of lysophosphatidic acid, and thus is useful for treating or preventing cardiovascular disease, cancer, metabolic disease, kidney disease, liver disease, inflammatory diseases, nervous disease, respiratory disease, desmoid disease, eye disease, cholestatic symptoms, other types of chronic pruritus or acute, or chronic rejection of transplanted organs.COPYRIGHT KIPO 2017

FeCl3·6H2O/acetaldehyde, a versatile system for the deprotection of ketals and acetals via a transacetalization process

Mild and efficient catalytic deprotection of ketals/acetals mediated by FeCl3·6H2O/acetaldehyde has been described in this paper. The versatility and high chemoselectivity of the iron(iii)/aldehyde system are demonstrated by a large scope of examples. Deprotected ketones/aldehydes are nearly quantitatively isolated after filtration over a pad of silica gel followed by evaporation of volatile by-products.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.